Nie-pinching the spine, puncturing Sifeng (EX-UE 10) plus Chinese herbs for pediatric anorexia due to dysfunction of spleen in transportation: a randomized controlled trial

Abstract

Objective

To observe the clinical efficacy of Nie-pinching the spine, puncturing Sifeng (EX-UE 10) plus Chinese herbs in treating pediatric anorexia due to dysfunction of spleen in transportation.

Methods

A total of 64 kids were randomized into an observation group and a control group by the random number table method, with 32 cases in each group. Patients in both groups received Jian Pi Kai Wei (strengthening spleen and stomach) powder according to pattern differentiation of traditional Chinese medicine (TCM). In addition, patients in the observation group received Nie-pinching the spine and puncturing Sifeng (EX-UE 10). Nie-pinching the spine was applied twice a week, and puncturing Sifeng (EX-UE 10) was performed once a week, with 2 weeks counted as 1 course of treatment. After 2 courses of treatment, the body mass index (BMI), peripheral blood leptin level and the microelements Zn, Fe and Se were compared at different time points (before treatment, after the first and second courses of treatment), as well as the therapeutic efficacy and onset time.

Results

After 2 courses of treatment, 31 cases in each group were evaluated. After the 1st course and the 2nd course, the BMI and serum Zn, Fe and Se levels in the observation group increased significantly (all P<0.05), the leptin level decreased substantially (both P<0.05); the BMI in the control group showed a substantial rise (P<0.05), while the Zn, Fe and Se levels slightly increased showing no statistical significance (all P>0.05), and the leptin level decreased but the difference showed no statistical significance (P>0.05). After the 1st and the 2nd courses of treatment, the BMI, serum Zn, Fe and Se levels increased more significantly (all P<0.05), and the serum leptin level decreased more significantly (both P<0.05) in the observation group than in the control group. After the 2nd course, the total effective rate and recovery rate in the observation group were both higher than those in the control group (both P<0.05), together with a quicker onset time (P<0.05).

Conclusion

Nie-pinching the spine, puncturing Sifeng (EX-UE 10) plus Chinese herbs is effective for pediatric anorexia due to dysfunction of spleen in transportation. It can decrease leptin, increase Zn, Fe and Se levels, alleviate apositic symptoms and increase BMI in the kids.

摘要

目的

观察捏脊、刺四缝穴加中药治疗脾失健运型小儿厌食的临床疗效。

方法

按随机数字表法将64例患儿 分为观察组和对照组, 每组32例。两组均根据中医辨证给予健脾开胃散治疗; 观察组在此基础上加用捏脊和刺四缝 穴, 捏脊每周2次, 针刺四缝穴每周1次, 连续2周为1疗程。治疗2个疗程后对比两组各时间点(治疗前, 治疗1个及2个 疗程后)体重指数(BMI)、患儿外周血中的血清瘦素(leptin)水平及微量元素锌、铁和硒的含量, 并比较两组治疗后临床 疗效及起效时间。

结果

2个疗程结束时, 两组各有31例获得治疗后评估。与本组治疗前比较, 观察组治疗第1及第2 疗程后, BMI及血清锌、铁及硒含量均明显升高(均P<0.05), leptin水平明显下降(均P<0.05); 对照组BMI升高明显 (P<0.05), 锌、铁及硒含量轻度升高, 但与治疗前差异无统计学意义(均P>0.05), leptin水平较治疗前下降, 但差异无 统计学意义(P>0.05)。与对照组比较, 观察组治疗第1个及第2个疗程后, BMI, 血清锌、铁和硒含量增加更明显 (均P<0.05), leptin水平下降更显著(均P<0.05)。观察组治疗2个疗程后的临床治愈率和总有效率均高于对照组 (均P<0.05), 且起效较对照组迅速(P<0.05)。

结论

捏脊、刺四缝穴加中药治疗脾失健运型厌食患儿的疗效确切, 可 有效降低患儿leptin, 提高锌、铁、硒的含量水平, 明显改善患儿的厌食症状, 并增加其BMI。