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Acupuncture for dry eye syndrome: a meta-analysis of randomized controlled trials

针刺治疗干眼症的Meta 分析

  • Systematic Review
  • Published:
Journal of Acupuncture and Tuina Science Aims and scope Submit manuscript

Abstract

Objective

To summarize and critically assess the evidence from randomized controlled trials (RCTs) of acupuncture in treating dry eye syndrome (DES) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the Cochrane Collaboration recommendations.

Methods

A search of PubMed, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Embase was made from their inception to August 2016, as well as Chinese, Japanese, and Korean databases. Two reviewers independently selected RCTs and assessed the methodological quality. Meta-analysis and the level of evidence were processed by RevMan 5.3 and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Results

After selection, 8 trials were subjected to our systematic review. The methodological quality was low generally. The 3-10 weeks follow-up showed that acupuncture improved the tear film break-up time (BUT) (MD=1.33, 95% CI=1.01-1.66, 619 participants). The mean difference of Schirmer’s test was 1.73 mm (95%CI=1.28-2.18, 618 participants) between the acupuncture group and the control group. The subjective variables exhibited no significant differences.

Conclusion

The low methodological quality of the trials does not suggest drawing firm conclusions on the value of acupuncture therapy for DES. Acupuncture treatment may have some effects on the tear film BUT and Schirmer’s test, but not on the subjective symptoms. Well-planned large-scale high-quality RCTs are needed to make it clear whether acupuncture is effective in treating DES.

摘要

目的

根据系统综述和meta 分析优先报告的条目(PRISMA)声明和Cochrane 协作中心推荐的方法, 严格 评估和总结针刺治疗干眼症的随机对照试验的结果。

方法

检索PubMed, Cochrane 临床试验注册中心, ClinicalTrials.gov 和Embase, 以及中文、日文和韩文数据库, 从建库时间到2016 年8 月。两位研究人员分别筛选 RCTs 并评估其方法学质量。采用Revman5.3 和GRADE 进行Meta 分析和证据分级。

结果

本系统评价共纳入8项试验, 其方法学质量普遍偏低。随访3-10 星期, 与对照组相比, 针刺治疗可以改善泪膜破裂时间(BUT, MD=1.33, 95% CI=1.01-1.66, 619 例)。针刺组和对照组之间Schirmer’s 试验的差值为1.73 mm (95% CI=1.28-2.18, 618 例)。 其他主观结局指标两组间无显著差异。

结论

由于目前纳入的临床试验方法学质量较低, 尚不能得出针刺治疗干 眼症疗效的确切结论。针刺疗法可能对BUT 和Schirmer’s 试验有一定影响, 但是对主观症状无明显作用。设计严 谨的大规模高质量随机对照试验将有助于明确针刺治疗干眼症的临床疗效。

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Acknowledgments

This work was supported by Scientific Research Projects of Shanghai Municipal Science and Technology Commission (上海市科学技术委员会科研项目, No. 11140900902, No. 14401971600, No. 14401933100); the Third Batch of Competitive Clinical Project of Traditional Chinese Medicine in Shanghai (上海市第三批中医临床优 势专科项目, No. ZYSNXD-YL-YSZK015); Shanghai Three-year Action Plan of Traditional Chinese Medicine (上海市中医药事业三年行动计划项目, No. CC-3-3051).

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Authors and Affiliations

  1. Acupuncture and Moxibustion Department, Shanghai First People’s Hospital, Shanghai, 200080, China

    Hui-ru Jiang  (蒋会茹), Su-jun Liu  (刘素君), Peng Liu  (刘鹏), Si-wei Xu  (徐斯伟), Yang Yang  (杨洋), Kai-yong Zhang  (张开勇), Yin Shou  (寿崟) & Bi-meng Zhang  (张必萌)

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  1. Hui-ru Jiang  (蒋会茹)
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Correspondence to Bi-meng Zhang  (张必萌).

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Jiang, Hr., Liu, Sj., Liu, P. et al. Acupuncture for dry eye syndrome: a meta-analysis of randomized controlled trials. J. Acupunct. Tuina. Sci. 15, 263–269 (2017). https://doi.org/10.1007/s11726-017-1011-1

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