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Hydrophobic interaction membrane chromatography for bioseparation and responsive polymer ligands involved

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Abstract

Hydrophobic interaction chromatography (HIC) is a rapid growing bioseparation technique, which separates biomolecules, such as therapeutic proteins and antibodys, based on the reversible hydrophobic interaction between immobilized hydrophobic ligands on chromatographic resin spheres and non-polar regions of solute molecule. In this review, the fundamental concepts of HIC and the factors that may affect purification efficiency of HIC is summarized, followed by the comparison of HIC with affinity chromatography and ion-exchange chromatography. Hydrophobic interaction membrane chromatography (HIMC) combines the advantages of HIC and membrane process and has showed great potential in bioseparation. For better understanding of HIMC, this review presents an overview of two main concerns about HIMC, i.e. membrane materials and hydrophobic ligands. Specifically, cellulose fiber-based membrane substrate and environment-responsive ligands are emphasized.

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Acknowledgement

The authors would like to thank the National Natural Science Foundation of China (Grant No. 20874004) for financial support.

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  1. Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China

    Jingling Chen, Rong Peng & Xiaonong Chen

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  1. Jingling Chen
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  2. Rong Peng
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Correspondence to Xiaonong Chen.

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Chen, J., Peng, R. & Chen, X. Hydrophobic interaction membrane chromatography for bioseparation and responsive polymer ligands involved. Front. Mater. Sci. 11, 197–214 (2017). https://doi.org/10.1007/s11706-017-0390-z

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