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Clinical factors associated with biochemical recurrence of prostate cancer with seminal vesicle invasion followed by robot-assisted radical prostatectomy: a retrospective multicenter cohort study in Japan (the MSUG94 group)

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Abstract

Locally advanced prostate cancer (PCa) with pathological seminal vesicle invasion (pT3b) is a very-high-risk disease associated with biochemical recurrence (BCR), local recurrence, distant metastases, or mortality following definitive therapies. This study aimed to evaluate the risk factors associated with BCR following robot-assisted radical prostatectomy (RARP) in PCa patients with pT3b. A retrospective multicenter cohort study was conducted on 3,195 patients with PCa who underwent RARP at nine domestic centers between September 2011 and August 2021. Biochemical recurrence-free survival (BRFS) after RARP in PCa patients with pT3b was the primary end-point of the study. The secondary end-point was to determine the association between BCR and covariates. We enrolled 188 PCa patients with pT3b. The median follow-up period was 32.8 months. At the end of the follow-up period, 76 patients (40.4%) developed BCR, of whom 15 (8.0%) were BCR at the date of surgery. The 1-, 2-, and 3-year BRFS rates were 76.4, 65.9, and 50.8%, respectively. Multivariate analysis identified initial prostate-specific antigen level and positive surgical margins (PSM) as significant predictors of BCR in PCa patients with pT3b undergoing RARP. In this study, we investigated the BRFS in PCa patients with pT3b. As PSM was an independent predictor of BCR in PCa patients with pT3b, these patients may require a combination of therapies to improve the BCR.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Urology, Gifu University Graduate School of Medicine, 1-1 Yanagito, Gifu, 501-1194, Japan

    Makoto Kawase & Takuya Koie

  2. Department of Urology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan

    Shin Ebara

  3. Department of Urology, Yokohama City University, Yokohama, Japan

    Tomoyuki Tatenuma & Kazuhide Makiyama

  4. Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu, Japan

    Takeshi Sasaki & Takahiro Inoue

  5. Department of Urology, University of Toyama, Toyama, Japan

    Yoshinori Ikehata & Hiroshi Kitamura

  6. Department of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan

    Akinori Nakayama & Kazutaka Saito

  7. Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

    Masahiro Toide & Fumitaka Koga

  8. Department of Urology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

    Tatsuaki Yoneda

  9. Department of Urology, Toranomon Hospital, Tokyo, Japan

    Kazushige Sakaguchi & Shinji Urakami

  10. Department of Urology, Kobe City Hospital Organization Kobe City Medical Center West Hospital, Kobe, Japan

    Jun Teishima

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  1. Makoto Kawase
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Contributions

MK: Data analysis, manuscript writing/editing; SE: Protocol/project development, data collection and management; TT: Data collection and management; TS: Data collection and management; YI: Data collection and management; AN: Data collection and management; MT: Data collection and management; TY: Protocol/project development, data collection and management; KS: Data collection and management; JT: Protocol/project development and supervision; KM: Protocol/project development and supervision; TI: Protocol/project development and supervision; HK: Protocol/project development and supervision; KS: Protocol/project development and supervision; FK: Protocol/project development and supervision; SU: Protocol/project development and supervision; TK: Protocol/project development, data management, manuscript writing/editing.

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Correspondence to Takuya Koie.

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Kawase, M., Ebara, S., Tatenuma, T. et al. Clinical factors associated with biochemical recurrence of prostate cancer with seminal vesicle invasion followed by robot-assisted radical prostatectomy: a retrospective multicenter cohort study in Japan (the MSUG94 group). J Robotic Surg 17, 1609–1617 (2023). https://doi.org/10.1007/s11701-023-01567-1

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