Skip to main content
Log in

Synthesis of novel indole derivatives containing double 1,3,4-oxadiazole moiety as efficient bactericides against phytopathogenic bacterium Xanthomonas oryzae

  • Original Paper
  • Published:
Chemical Papers Aims and scope Submit manuscript

Abstract

A series of novel indole derivatives containing double 1,3,4-oxadiazole moiety was designed, synthesized and evaluated for their antibacterial activities in vitro. These compounds were fully characterized by 1H NMR, 13C NMR, and HRMS. Bioassay results indicated that most of title compounds exhibited excellent antibacterial activities against rice bacterial pathogen Xanthomonas oryzae (Xoo). For example, compounds 7d, 7h, 7i, 7j, 7k, 7l and 7m had the half-maximal effective concentration (EC50) values of 52.31, 54.12, 40.65, 38.80, 51.13, 52.75 and 50.66 µg/mL, respectively, which was better than that of commercial product bismerthiazol (BMT) (85.18 µg/mL). The experimental results proved that indole derivatives bearing double 1,3,4-oxadiazole unit are promising candidates for the development of new agricultural bactericides against pathogenic bacterium Xoo.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Scheme 1

Similar content being viewed by others

References

Download references

Acknowledgements

This research was financially supported by the Project Enterprises and Business (H 110029), the Scientific Research Foundation of Guizhou University (no. 201542), and Guizhou Science Technology Program (no. 20161055), the Young Talents Scientific Research Foundation of Guizhou Education Department (no. 2017).

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Gui-Ping Ouyang or Zhen-Chao Wang.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 2361 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tian, K., Li, XQ., Zhang, L. et al. Synthesis of novel indole derivatives containing double 1,3,4-oxadiazole moiety as efficient bactericides against phytopathogenic bacterium Xanthomonas oryzae. Chem. Pap. 73, 17–25 (2019). https://doi.org/10.1007/s11696-018-0555-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11696-018-0555-y

Keywords

Navigation