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Laparoscopic One Anastomosis Gastric Bypass Versus Laparoscopic Roux-en-Y Gastric Bypass Effects on Pre-existing Mild-to-Moderate Gastroesophageal Reflux Disease in Patients with Obesity: a Randomized Controlled Study

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Abstract

Background

Patients with obesity having GERD usually undergo Roux-en-Y gastric bypass (RYGB) as the procedure of choice. However, the emergence of one anastomosis gastric bypass (OAGB) as a less time-consuming operation with fewer complications offers a potential option for these patients.

Study Design

This randomized controlled trial included 80 patients (out of 457 screened) with mild-to-moderate GERD that were equally divided into two groups for OAGB and RYGB. GERD was diagnosed by 20-item questionnaire, upper endoscopy, 24-h pH monitoring, and manometry. Follow-up at 6 and 12 months was done.

Results

No significant differences were found between the two groups regarding demographic data, comorbidities, and weight loss. OAGB had less operative time and fewer complications. Both procedures had comparable favorable effects in reducing the GERD symptoms evidenced by upper endoscopy, 24-h pH monitoring, and manometry.

Conclusion

OAGB is a promising bariatric procedure in weight loss for patients with obesity having mild-to-moderate GERD (up to grade B esophagitis by Los Angeles score). Furthermore, wide-scale studies and on more severe degrees of GERD are required to fully understand its benefits in GERD patients with obesity.

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Authors and Affiliations

  1. General Surgery, Faculty of Medicine, Ain Shams University, Cairo, 11591, Egypt

    Moheb S. Eskandaros, Mohamed H. Zaid & Ahmed A. Darwish

  2. Cairo, Egypt

    Alaa Abbass

Authors
  1. Moheb S. Eskandaros
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  2. Alaa Abbass
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  3. Mohamed H. Zaid
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  4. Ahmed A. Darwish
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Corresponding author

Correspondence to Moheb S. Eskandaros.

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Ethics Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Key Points

• No significant differences between the two groups in weight loss at 1 year postoperatively.

• OAGB had less operative time and fewer complications.

• OAGB and RYGB had similar effects in reducing mild-to-moderate GERD evidenced by UGI, 24-h pH monitoring, and manometry.

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Eskandaros, M.S., Abbass, A., Zaid, M.H. et al. Laparoscopic One Anastomosis Gastric Bypass Versus Laparoscopic Roux-en-Y Gastric Bypass Effects on Pre-existing Mild-to-Moderate Gastroesophageal Reflux Disease in Patients with Obesity: a Randomized Controlled Study. OBES SURG 31, 4673–4681 (2021). https://doi.org/10.1007/s11695-021-05667-5

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  • DOI: https://doi.org/10.1007/s11695-021-05667-5

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