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Efficacy of Intragastric Balloons for Weight Loss in Overweight and Obese Adults: a Systematic Review and Meta-analysis of Randomized Controlled Trials

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Abstract

Intragastric balloons (IGB) are the most widely used endoscopic bariatric and metabolic therapies. We aimed to evaluate the efficacy of IGB in comparison with sham or lifestyle interventions for weight loss in overweight and obese patients. This systematic review and meta-analysis was performed following the PRISMA guidelines. Electronic searches were performed to identify randomized controlled trials, which compared IGB with sham or lifestyle intervention. Thirteen RCTs with 1523 patients were included. The difference in mean %EWL and %TWL at follow-up was 17.98%, and 4.40%, respectively, which was significantly higher in the IGB group. Similarly, the difference in mean AWL and BMIL was 6.12 kg, and 2.13 kg/m2, respectively. IGB therapy is more effective than lifestyle intervention alone for weight loss in overweight and obese adults.

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Authors and Affiliations

  1. Gastrointestinal Endoscopy Unit, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil

    Ana Paula Samy Tanaka Kotinda, Diogo Turiani Hourneaux de Moura, Igor Braga Ribeiro, Alberto Machado da Ponte Neto, Igor Mendonça Proença, Marcelo Mochate Flor, Wanderley Marques Bernardo & Eduardo Guimarães Hourneaux de Moura

  2. Av. Dr Enéas de Carvalho Aguiar, 225, 6o andar, bloco 3, Cerqueira Cesar, São Paulo, SP, 05403-010, Brazil

    Igor Braga Ribeiro

  3. Division of Gastroenterology, West Virginia University Health Sciences Center Charleston Division, Charleston, WV, USA

    Shailendra Singh

  4. University of São Caetano do Sul, São Paulo, Brazil

    Karina Lopes de Souza

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  1. Ana Paula Samy Tanaka Kotinda
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  2. Diogo Turiani Hourneaux de Moura
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  10. Eduardo Guimarães Hourneaux de Moura
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Contributions

Kotinda, APST: acquisition of data, analysis, interpretation of data, drafting the article, revising the article, and final approval; Moura, DTH: analysis and interpretation of data and revising the article; Ribeiro, IB: acquisition of data, drafting the article, revising the article, and final approval; Shailendra, S: revising, editing, and drafting article and final approval. Ponte Neto, AM: revising, editing, and drafting article and final approval; Proença, IM: revising, editing, and drafting article and final approval; Flor, MM: revising, editing, and drafting article and final approval; Souza, KL: revising, editing, and drafting article and final approval; Bernardo, WM: revising, editing, and drafting article and final approval; and de Moura, EGH: analysis and interpretation of data, drafting the article, revising the article and final approval.

Corresponding author

Correspondence to Igor Braga Ribeiro.

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Conflict of Interest

Dr. Moura reports personal fees from Boston Scientific, personal fees from Olympus, outside the submitted work. All other authors declare that they have no conflict of interest.

Ethical Statement

This study was approved by the ethics committee of Hospital das Clínicas, Faculty of Medicine, University of São Paulo.

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As this study is a systematic review with meta-analysis, the informed consent does not apply.

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Kotinda, A.P.S.T., de Moura, D.H., Ribeiro, I.B. et al. Efficacy of Intragastric Balloons for Weight Loss in Overweight and Obese Adults: a Systematic Review and Meta-analysis of Randomized Controlled Trials. OBES SURG 30, 2743–2753 (2020). https://doi.org/10.1007/s11695-020-04558-5

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