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Legend of Weight Loss: a Crosstalk Between the Bariatric Surgery and the Brain

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Abstract

In recent years, plenty of researches have reported in obese individuals with abnormal brain processes implicated in homeostatic regulation, reward, emotion, memory, attention, and executive function in eating behaviors. Thus, treating obesity cannot remain “brainless.” Behavioral and psychological interventions activate the food reward, attention, and motivation system, leading to minimal weight loss and high relapse rates. Pharmacotherapy is an effective weight loss method and regulate brain activity but with concerns about its brain function safety problems. Obesity surgery, the most effective therapy currently available for obesity, shows pronounced effects on brain activity, such as deactivation of reward and attention system, and activation of inhibition control toward food cues. In this review, we present an overview of alterations in the brain after the three common weight loss methods.

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Acknowledgments

We would like to thank Dr. Aaron M Gusdon (University of Texas Health Science Center at Houston) for discussion and critical reading of the manuscript.

Funding

The work was supported by the National Key R&D Program of China (No. 2018YFC1314100), National Natural Science Foundation of China (81970677), and National Natural Science Foundation of China for Youth (81500687).

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Authors and Affiliations

  1. Endocrinology and Metabolism Center, National Metabolic Management Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China

    Ziwei Lin

  2. Endocrinology and Metabolism Center, National Metabolic Management Center, Division of Metabolic Surgery for Obesity and Diabetes, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Rd, Shanghai, 200072, People’s Republic of China

    Shen Qu

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  1. Ziwei Lin
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Correspondence to Shen Qu.

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Lin, Z., Qu, S. Legend of Weight Loss: a Crosstalk Between the Bariatric Surgery and the Brain. OBES SURG 30, 1988–2002 (2020). https://doi.org/10.1007/s11695-020-04474-8

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