Abstract
Objective
To evaluate the impact of obesity on surgical outcomes for women with endometrial cancer (EC) managed by laparoscopic surgery. Minimal invasive surgery has been incorporated in the surgical management of EC, improving perioperative outcomes. However, this approach may become more challenging in case of obesity. So it is important to accurately evaluate and establish the most appropriate surgical approach for these patients.
Materials and Methods
From January 2008 through April 2016, we conducted a prospective observational study, including all consecutive patients with a histological diagnosis of EC undergoing surgical staging by laparoscopy at our institution. Patients were classified in two groups (obese vs non-obese) according to their body mass index. Information about short- and long-term outcomes were recorded and analyzed during an outpatient follow-up.
Results
Between January 2008 and April 2016, 83 women underwent laparoscopic surgery for EC at our institution. Forty-six (56.6%) of them were classified as obese. Surgical outcomes were similar in both groups. No significant difference was reported in surgical time, number of lymph nodes removed, blood loss, length of hospital stay, and incidence of intra- or postoperative complications. Also, long-term outcomes did not show any statistical significant difference: recurrence rate was 6.4% (3/47) among obese patients and 13.9% (5/36) among non-obese (p = 0.251). No difference was reported even in time to recurrence (log-rank p = 0.280) and in survival time (log-tank p = 0.132) between the two groups.
Conclusions
Our results show that obesity did not impair the outcomes of laparoscopic surgery for EC. This surgical approach may be offered to obese patients with the same level of safety, radicality, and efficiency as for the normal-weight population.
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References
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30.
Kondalsamy-Chennakesavan S, Janda M, Gebski V, et al. Risk factors to predict the incidence of surgical adverse events following open or laparoscopic surgery for apparent early stage endometrial cancer: results from a randomised controlled trial. Eur J Cancer. 2012;48:2155–62.
Shaw E, Farris M, McNeil J, et al. Obesity and endometrial cancer. Recent Results Cancer Res. 2016;208:107–36.
Bittoni MA, Fisher JL, Fowler JM, et al. Assessment of the effects of severe obesity and lifestyle risk factors on stage of endometrial cancer. Cancer Epidemiol Biomark Prev. 2013;22:76–81.
Mahdi H, Jernigan AM, Alijebori Q, et al. The impact of obesity on the 30-day morbidity and mortality after surgery for endometrial cancer. J Minim Invasive Gynecol. 2015;22:94–102.
Schmandt RE, Iglesas DA, Co NN, et al. Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol. 2011;205:518–25.
Abu-Rustum NR. Sentinel lymph node mapping for endometrial cancer: a modern approach to surgical staging. J Natl Compr Cancer Netw. 2014;12:288–97.
Gunderson CC, Java J, Moore KN, et al. The impact of obesity on surgical staging, complications, and survival with uterine cancer: gynecologic oncology group LAP2 ancillary data study. Gynecol Oncol. 2014;133:23–7.
Palomba S, Falbo A, Mocciaro R, et al. Laparoscopic treatment for endometrial cancer: a meta-analysis of randomized controlled trials. Gynecol Oncol. 2009;112:415–21.
Mourits MJ, Bijen CB, Arts HJ, et al. Safety of laparoscopy versus laparotomy in early-stage endometrial cancer: a randomized trial. Lancet Oncol. 2010;11:762–71.
Walker JL, Piedmonte MR, Spirtos NM, et al. Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 Study. J Clin Oncol. 2012;30:695–700.
Walker JL, Piedmonte MR, Spirtos NM, et al. Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2. J Clin Oncol. 2009;27:5331–6.
Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 2009;105:103–4.
Von Gruenigen VE, Gil KM, Frasure HE, et al. The impact of obesity and age on quality of life in gynecologic surgery. Am J Obstet Gynecol. 2005;193:1369–75.
Catalán V, Gómez-Ambrosi J, Rodríguez A, et al. Adipose tissue immunity and cancer. Front Physiol. 2013;4:275.
Perez-Hernandez AI et al. Mechanisms linking excess adiposity and carcinogenesis promotion. Front Endocrinol. 2014;5:65.
Gomez-Ambrosi J et al. Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin Biochem. 2002;35:315–20.
Catalán V, Gómez-Ambrosi J, Rodríguez A, et al. Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Clin Endocrinol. 2008;68:213–9.
Gómez-Ambrosi J, Salvador J, Rotellar F, et al. Increased serum amyloid a concentrations in morbid obesity decrease after gastric bypass. Obes Surg. 2006;16:262–9.
Gallego-Escuredo JM, Gómez-Ambrosi J, Catalan V, et al. Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients. Int J Obes. 2015;39:121–9.
Kazaure HS, Roman SA, Sosa JA. Obesity is a predictor of morbidity in 1,629 patients who underwent adrenalectomy. World J Surg. 2011;35:1287–95.
Suidan RS, He W, Sun CC, et al. Impact of body mass index and operative approach on surgical morbidity and costs in women with endometrial carcinoma and hyperplasia. Gynecol Oncol. 2017;145:55–60.
Uccella S, Bonzini M, Palomba S, et al. Impact of obesity on surgical treatment for endometrial cancer: a multicenter study comparing laparoscopy vs open surgery, with propensity-matched analysis. J Minim Invasive Gynecol. 2016;23:53–61.
O’Hanlan JA, Dibble SL, Fisher DT. Total laparoscopic hysterectomy for uterine pathology: impact of body mass index on outcomes. Gynecol Oncol. 2006;103:938–41.
Helm CW, Arumugam C, Gordinier ME, et al. Laparoscopic surgery for endometrial cancer: increasing body mass index does not impact postoperative complications. J Gynecol Oncol. 2011;22:168–76.
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Gambacorti-Passerini, Z.M., López-De la Manzanara Cano, C., Pérez Parra, C. et al. Obesity in Patients with Endometrial Cancer: May It Affect the Surgical Outcomes of Laparoscopic Approach?. OBES SURG 29, 3285–3290 (2019). https://doi.org/10.1007/s11695-019-03986-2
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DOI: https://doi.org/10.1007/s11695-019-03986-2