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Small Intestinal Bypass Induces a Persistent Weight-Loss Effect and Improves Glucose Tolerance in Obese Rats

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Abstract

Background

This study investigated the role of proximal small intestinal bypass (PSIB) and distal small intestinal bypass (DSIB) as well as their long-term effects on weight loss and glucose metabolism in high-sugar and high-fat diet-induced obese rats.

Methods

Sprague-Dawley rats were divided into four groups: PSIB, bypassing 60% of the proximal small intestine length; DSIB, bypassing 60% of the distal small intestine length; sham-operated (Sham) animals; and control animals. All rats were fed a high-sugar and high-fat diet after surgery. The primary outcome measures were body weight, food intake, fasting blood glucose (FBG) levels, oral glucose tolerance test (OGTT), and the insulin tolerance test (ITT).

Results

Global body weight (BW) and food intake in the PSIB and DSIB groups were lower than those in the Sham group at postoperative week 2. BW and food intake in the PSIB group were lower than those in the DSIB group at postoperative week 24. The PSIB and DSIB groups exhibited improvement in glucose tolerance at postoperative weeks 4, 8, and 24. The PSIB and DSIB groups exhibited improvement in FBG at postoperative week 24, and only the DSIB group exhibited improvement in insulin sensitivity.

Conclusions

This study provides experimental evidence that PSIB surgery induced a better and more persistent weight loss effect than DSIB surgery and that the two types of intestinal bypass surgeries yielded equivalent and stable long-term improvement in glucose tolerance in an obese rat model.

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Authors and Affiliations

  1. Department of General Surgery, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, No.1 Minde Road, Nanchang, Jiangxi Province, 330006, People’s Republic of China

    Jiaqing Cao, Quan Ren & Jinyuan Duan

  2. Department of Women’s Health, Maternal and Child Health Hospital of Jiangxi Province, Nanchang, 330006, China

    Cai Tan

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  1. Jiaqing Cao
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  2. Quan Ren
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  4. Jinyuan Duan
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Correspondence to Jinyuan Duan.

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Conflict of Interest

All of the authors declare no conflicts of interest.

Source of Funding

This work was supported by the National Natural Science Foundation of China (no.81500652), the Natural Science Foundation of Jiangxi Province (no.20161BAB215247), the Foundation of Education Department of Jiangxi Province (no. GJJ150133), and the Foundation of Health and Family Planning Commission of Jiangxi Province (no. 20171072, no.20171091).

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Cao, J., Ren, Q., Tan, C. et al. Small Intestinal Bypass Induces a Persistent Weight-Loss Effect and Improves Glucose Tolerance in Obese Rats. OBES SURG 27, 1859–1866 (2017). https://doi.org/10.1007/s11695-017-2571-3

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  • DOI: https://doi.org/10.1007/s11695-017-2571-3

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