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Preoperative Predictive Factors of Successful Weight Loss and Glycaemic Control 1 Year After Gastric Bypass for Morbid Obesity

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An Erratum to this article was published on 01 March 2016

Abstract

Background

Gastric bypass (GBP) is one of the most effective surgical procedures to treat morbid obesity and the related comorbidities. This study aimed at identifying preoperative predictors of successful weight loss and type 2 diabetes mellitus (T2DM) remission 1 year after GBP.

Methods

Prospective longitudinal study of 771 patients who underwent GBP was performed at four Italian centres between November 2011 and May 2013 with 1-year follow-up. Preoperative anthropometric, metabolic and social parameters, the surgical technique and the previous failed bariatric procedures were analyzed. Weight, the body mass index (BMI), the percentage of excess weight lost (% EWL), the percentage of excess BMI lost (% BMIL) and glycated haemoglobin (HbA1c) were recorded at follow-up.

Results

Univariate and multivariate analysis showed that BMI <50 kg/m2 (p = 0.006) and dyslipidaemia (p = 0.05) were predictive factors of successful weight loss. Multivariate analysis of surgical technique showed significant weight loss in patients with a small gastric pouch (p < 0.001); the lengths of alimentary and biliary loops showed no statistical significance. All diabetic patients had a significant reduction of HbA1c (p < 0.001) after surgery. BMI ≥ 50 kg/m2 (p = 0.02) and low level of preoperative HbA1c (p < 0.01) were independent risk factors of T2DM remission after surgery.

Conclusions

This study provides a useful tool for making more accurate predictions of best results in terms of weight loss and metabolic improvement.

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Acknowledgments

We would like to acknowledge Dr. Eugenia Dal Fovo for translating this article and Dr Fabiola Giudici for statistical analysis.

Informed consent was obtained from all individual participants included in the study.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of Interest

Silvia Palmisano: no conflict of interest.

Marta Silvestri: no conflict of interest.

Michela Giuricin: no conflict of interest.

Nicolò de Manzini: no conflict of interest.

Edoardo Baldini: no conflict of interest.

Simone Albertario: no conflict of interest.

Patrizio Capelli: no conflict of interest.

Bernardo Marzano: no conflict of interest.

Giovanni Fanti: no conflict of interest.

Aron Zompichiatti: no conflict of interest.

Paolo Millo: no conflict of interest.

Massimiliano Fabozzi: no conflict of interest.

Riccardo Brachet Contul: no conflict of interest.

Elisa Ponte: no conflict of interest.

Rosaldo Allieta: no conflict of interest.

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Authors and Affiliations

  1. Department of Medical, Surgical and Health Sciences, General Surgery Clinic, University Hospital of Trieste, Strada di Fiume, 447, Trieste, Italy

    Silvia Palmisano, Marta Silvestri, Michela Giuricin & Nicolò de Manzini

  2. Unità Operativa di Chirurgia Generale, Toracica e Vascolare, Ospedale “Guglielmo da Saliceto”, via Taverna 49, 29122, Piacenza, Italy

    Edoardo Baldini, Simone Albertario & Patrizio Capelli

  3. Department of Surgery, Santa Maria degli Angeli Hospital, Via Montereale 24, 33170, Pordenone, Italy

    Bernardo Marzano, Giovanni Fanti & Aron Zompicchiatti

  4. Department of General Surgery, Bariatric and Metabolic Unit, “Umberto Parini” Regional Hospital of Aosta, Viale Ginevra 3, Aosta, Italy

    Paolo Millo, Massimiliano Fabozzi, Riccardo Brachet Contul, Elisa Ponte & Rosaldo Allieta

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  1. Silvia Palmisano
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Correspondence to Silvia Palmisano.

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Palmisano, S., Silvestri, M., Giuricin, M. et al. Preoperative Predictive Factors of Successful Weight Loss and Glycaemic Control 1 Year After Gastric Bypass for Morbid Obesity. OBES SURG 25, 2040–2046 (2015). https://doi.org/10.1007/s11695-015-1662-2

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