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Effect of Roux-en-y Gastric Bypass on Nonalcoholic Fatty Liver Disease Evaluated Through NAFLD Fibrosis Score: a Prospective Study

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Abstract

Background

Nonalcoholic fatty liver disease (NAFLD) is common among subjects who undergo bariatric surgery and its postsurgical improvement has been reported. This study aimed to determine the evolution of liver disease evaluated through NAFLD fibrosis score 12 months after surgery.

Methods

It is a prospective cohort study which evaluated patients immediately before and 12 months following Roux-en-Y gastric bypass (RYGB).

Results

Mean score decreased from 1.142 to 0.066; surgery led to a resolution rate of advanced fibrosis of 55 %. Resolution was statistically associated with female gender, percentage of excess weight loss, postsurgical body mass index, postsurgical platelet count, and diabetes resolution.

Conclusions

As previously reported by studies in which postsurgical biopsies were performed, RYGB leads to a great resolution rate of liver fibrosis. Since postsurgical biopsy is not widely available and has a significant risk, calculation of NAFLD fibrosis score is a simple tool to evaluate this evolution through a noninvasive approach.

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Conflict of Interest

Everton Cazzo, Laisa Simakawa Jimenez, José Carlos Pareja, and Elinton Adami Chaim declared that they have no conflict of interest.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in the study.

Statement of Human and Animal Rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Authors and Affiliations

  1. Department of Surgery; Faculty of Medical Sciences, State University of Campinas (UNICAMP), R. Alexander Fleming, Campinas, SP, 13083-887, Brazil

    Everton Cazzo, Laísa Simakawa Jimenez, José Carlos Pareja & Elinton Adami Chaim

Authors
  1. Everton Cazzo
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  2. Laísa Simakawa Jimenez
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  3. José Carlos Pareja
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  4. Elinton Adami Chaim
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Correspondence to Everton Cazzo.

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Cazzo, E., Jimenez, L.S., Pareja, J.C. et al. Effect of Roux-en-y Gastric Bypass on Nonalcoholic Fatty Liver Disease Evaluated Through NAFLD Fibrosis Score: a Prospective Study. OBES SURG 25, 982–985 (2015). https://doi.org/10.1007/s11695-014-1489-2

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  • DOI: https://doi.org/10.1007/s11695-014-1489-2

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