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Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review

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Abstract

Purpose

Intestinal protozoan parasites are responsible for diarrheal diseases causing significant morbidity and mortality. Entamoeba histolytica is the principle protozoan parasite associated with diarrheal infections. The infection is often associated with inaccessibility to clean drinking water and poor sanitary conditions in low- and middle-income countries including India. A comprehensive systematic review was performed to evaluate a reliable nationwide estimate for prevalence and geographic distribution of amoebiasis in India and the complications associated with it.

Methods

We used the PRISMA guidelines to perform a systematic review and meta-analysis of articles published between the year 2001–2020. Two English language databases PubMed and Web of Science were searched to achieve relevant studies.

Results

Initial searches resulted in 467 studies out of which 64 eligible articles involving data from 289,659 human subjects from 12 states and 4 union territories were included in the final analysis. Prevalence of amoebiasis ranged from 3-23% in asymptomatic population, 0.64–11% in symptomatic patients and 1–17.5% in HIV-infected patients. Highest prevalence was seen in Tamil Nadu, Andaman Nicobar Island and North East India. Extra intestinal invasion of Entamoeba histolytica leading to complications such as amoebic liver abscess, amoebic colitis, colonic perforation and ameboma were also reported. Such complications have the potential to increase healthcare burden and may prove to be fatal.

Conclusion

Amoebiasis remains a significant public health issue in India responsible for diarrheal diseases causing significant morbidity and mortality. Entamoeba histolytica is the principle protozoan parasite associated with amoebiasis. Public health efforts should be directed towards its control and better diagnostic methods should be employed for distinguishing between pathogenic and non-pathogenic species of Entamoeba.

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Authors and Affiliations

  1. Department of Microbiology, Central University of Punjab, Bathinda, Punjab, 151401, India

    Palak Gupta, Ashutosh Balodhi, Khushi Jain & Nasir Salam

  2. Department of Geography, Central University of Punjab, Bathinda, Punjab, 151401, India

    Kiran Kumari Singh

  3. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India

    Farah Deeba

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  1. Palak Gupta
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Gupta, P., Singh, K.K., Balodhi, A. et al. Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review. Acta Parasit. 67, 947–961 (2022). https://doi.org/10.1007/s11686-022-00547-z

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