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Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirus disease 2019 (COVID-19). The pandemic is considered a significant threat to global public health till now. In this review, we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2, including its prototype and variants. The overall clinical features of variants of concern (VOC), heterogeneity in the clinical manifestations, radiology and pathology of COVID-19 patients are also discussed, along with advances in therapeutic agents.

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Acknowledgements

This work is supported by Shanghai Municipal Key Clinical Specialty (No. shslczdzk02202), Shanghai Top-Priority Clinical Key Disciplines Construction Project (No. 2017ZZ02014), Shanghai Key Laboratory of Emergency Prevention, Diagnosis, and Treatment of Respiratory Infectious Diseases (No. 20dz2261100) and Cultivation Project of Shanghai Major Infectious Disease Research Base (No. 20dz2210500).

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Authors and Affiliations

  1. Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Dong Wei & Xinxin Zhang

  2. Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Yusang Xie, Xuefei Liu, Rong Chen, Min Zhou & Jieming Qu

  3. Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Yusang Xie, Xuefei Liu, Rong Chen, Min Zhou & Jieming Qu

  4. Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, 200025, China

    Yusang Xie, Xuefei Liu, Rong Chen, Min Zhou & Jieming Qu

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  1. Dong Wei
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  3. Xuefei Liu
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  4. Rong Chen
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  5. Min Zhou
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  6. Xinxin Zhang
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  7. Jieming Qu
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Corresponding author

Correspondence to Jieming Qu.

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Conflicts of interest Dong Wei, Yusang Xie, Xuefei Liu, Rong Chen, Min Zhou, Xinxin Zhang, and Jieming Qu declare that they have no conflict of interest.

This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Wei, D., Xie, Y., Liu, X. et al. Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China. Front. Med. 17, 1030–1046 (2023). https://doi.org/10.1007/s11684-023-1043-5

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  • DOI: https://doi.org/10.1007/s11684-023-1043-5

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