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18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma

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Abstract

Epileptogenic hypothalamic hamartoma is characterized by intractable gelastic seizures. A systematic analysis of the overall brain metabolic pattern in patients with hypothalamic hamartoma (HH) could facilitate the understanding of the epileptic brain network and the associated brain damage effects of HH. In this study, we retrospectively evaluated 27 patients with epileptogenic HH (8 female patients; age, 2–33 years) by using 18F-fluorodeoxyglucose-positron emission tomography. The correlations among tomography result, seizure type, sex, and structural magnetic resonance imaging were assessed. Whole metabolic patterns and voxel-based morphometry findings were assessed by group analysis with healthy controls. Assessment of the whole metabolic pattern in patients with HH revealed several regional metabolic reductions in the cerebrum and an overall metabolic reduction in the cerebellum. In addition, areas showing hypometabolism in the neocortex were more widely distributed ipsilaterally than contralaterally to the HH. Reductions in glucose metabolism and gray matter volume in the neocortex were predominant ipsilateral to the HH. In conclusion, the glucose hypometabolism pattern in patients with epileptogenic HH involved the neocortex, subcortical regions, and cerebellum. The characteristics of glucose hypometabolism differed across seizure type and sex. Reductions in glucose metabolism and structural changes may be based on different mechanisms, but both are likely to occur ipsilateral to the HH in the neocortex. We hypothesized that the dentato-rubro-thalamic tract and cerebro-ponto-cerebellar tract, which are responsible for intercommunication between the cerebral cortex, subcortical regions, and cerebellar regions, may be involved in a pathway related to seizure propagation, particularly gelastic seizures, in patients with HH.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81801288, 81871009, and 82030037)

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  1. The two authors contributed equally to this article.

Authors and Affiliations

  1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

    Chao Lu, Kailiang Wang, Fei Meng, Yihe Wang, Yongzhi Shan, Penghu Wei & Guoguang Zhao

  2. China International Neuroscience Institute (CHINA-INI), Beijing, 100053, China

    Chao Lu, Kailiang Wang, Fei Meng, Yihe Wang, Yongzhi Shan, Penghu Wei & Guoguang Zhao

  3. Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing, 100069, China

    Guoguang Zhao

Authors
  1. Chao Lu
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  2. Kailiang Wang
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  3. Fei Meng
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  4. Yihe Wang
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  5. Yongzhi Shan
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  7. Guoguang Zhao
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Correspondence to Yongzhi Shan, Penghu Wei or Guoguang Zhao.

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Compliance with ethics guidelines

Chao Lu, Kailiang Wang, Fei Meng, Yihe Wang, Yongzhi Shan, Penghu Wei, and Guoguang Zhao declare that they have no conflicts of interest. All procedures were conducted in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients for inclusion in the study.

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Lu, C., Wang, K., Meng, F. et al. 18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma. Front. Med. 15, 913–921 (2021). https://doi.org/10.1007/s11684-021-0874-1

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