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Machine perfusion versus cold storage of livers: a meta-analysis

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Abstract

Different organ preservation methods are key factors influencing the results of liver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death (DCD) livers preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysis. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and hyaluronic acid (HA) and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow (PVF). Alkaline phosphatase (ALP) levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, 710061, China

    Sushun Liu, Qing Pang, Jingyao Zhang, Mimi Zhai, Sinan Liu & Chang Liu

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  1. Sushun Liu
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  2. Qing Pang
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Correspondence to Chang Liu.

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Liu, S., Pang, Q., Zhang, J. et al. Machine perfusion versus cold storage of livers: a meta-analysis. Front. Med. 10, 451–464 (2016). https://doi.org/10.1007/s11684-016-0474-7

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