Abstract
Background
Impaired visual mental imagery is an important symptom of depression and has gradually become an intervention target for cognitive behavioral therapy.
Methods
Our study involved a total of 25 healthy controls (HC) and 23 individuals with moderate depressive symptoms (MD). This study explored the attentional mechanism supporting visual mental imagery impairments in depression using the Vividness of Visual Imagery Questionnaire (VVIQ), attentional network test (ANT), and resting-state functional magnetic resonance imaging (rs-fMRI). The intrinsic activity of attention-related regions relative to those supporting visual mental imagery was identified in depression patients. In addition, a meta-analysis was used to describe the cognitive function related to this intrinsic activity.
Results
The global correlation (GCOR) of the right anterior fusiform gyrus (FG) was decreased in depression patients. Attention-related areas were concentrated in the right posterior FG; the anterior and posterior functional connectivity (FC) of the FG was decreased in depression patients. Graph theoretic analysis showed that the degree of the right anterior FG was decreased, the degree of the anterior insula was increased, and the negative connection between these two regions was strengthened in depression patients. In addition, the degree of the right anterior FG, the FC between the subregions of the right FG, and the FC between the right anterior FG and insula were correlated with VVIQ scores; however, this correlation was not significant in depression patients. The meta-analysis suggested that the changes in the anterior FG in depressed patients may stem from difficulties of semantic memory retrieval.
Conclusion
The changed intrinsic activity of subregions of the FG relative to the semantic memory retrieval may be associated with visual mental imagery impairments in depression.
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Data availability
The data that support the findings of this study are not publicly available due to their containing information that could compromise the privacy of research participants, but are available after the corresponding author agree to authorize.
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Acknowledgements
We thank South China Normal University for its contributions to the data analysis in this study. As the undertaking affiliation of the study, Guangdong Provincial Hospital of Traditional Chinese Medicine greatly helped with the participant recruitment and data collection of this study. This study was performed with the support by the Key-Area Research and Development Program of Guangdong Provincial (2020B1111100007). We are also very grateful to the participants who cooperated with us to complete this study.
Funding
Key-Area Research and Development Program of Guangdong Province (2020B1111100007). “High quality development, inheritance, innovation and improvement Project of Chinese Medicine” of Department of Finance of Guangdong Province, Yuecaishe (No. [2022] 102). Guangzhou University of Chinese Medicine “Double First-Class” and High-level University Discipline Collaborative Innovation Team (2021xk22).
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Jun-He Zhou, and Di Wang were responsible for the writing of this article and most of the data analysis. De-Long Zhang, Chang-Hong Li, and Zeng-Jian Wang were responsible for making corrections to the paper and guiding the analysis methods. Wen-Bin Fu is in charge of the study design., Bai-Le Ning, Ying Deng, Xue-Song Liang, Xi-Chang Huang, and Bin-Kun Huang were responsible for data collection. was responsible for part of the data analysis.
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Zhou, JH., Huang, BK., Wang, D. et al. Subregions of the fusiform gyrus are differentially involved in the attentional mechanism supporting visual mental imagery in depression. Brain Imaging and Behavior (2024). https://doi.org/10.1007/s11682-024-00885-8
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DOI: https://doi.org/10.1007/s11682-024-00885-8