Abstract
To examine the corpus callosum’s (CC) integrity in terms of fractional anisotropy (FA) and how it affects resting-state hemispheric connectivity (rs-IHC) and cognitive function in healthy individuals. Sixty-eight healthy individuals were recruited for the study. The global FA (gFA) and FA values of each CC tract (forceps minor, body, tapetum, and forceps major) were evaluated using diffusion-weighted imaging (DWI) sequences. The homotopic functional connectivity technique was used to quantify the effects of FA in the CC tracts on bilateral functional connectivity, including the confounding effect of gFA. Brain regions with higher or lower rs-IHC were identified using the threshold-free cluster enhancement family-wise error-corrected p-value of 0.05. The null hypothesis was rejected if the p-value was ≤ 0.05 for the nonparametric partial correlation technique. Several clusters of increased rs-IHC were identified in relation to the FA of individual CC tracts, each with a unique topographic distribution and extension. Only forceps minor FA values correlated with cognitive scores. The integrity of CC influences rs-IHC differently in healthy subjects. Specifically, forceps minor anisotropy impacts rs-IHC and cognition more than other CC tracts do.
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Data availability
The dataset analyzed during the current study derives from the public dataset “Leipzig Study for Mind–Body-Emotion Interactions” (LEMON) (Babayan et al., 2019); in the publication is reported the link to the data repository.
All data generated specifically for the analyses of this study are included in this published article (and its supplemental information file).
Abbreviations
- 3DT1-MP2RAGE:
-
3D T1-weighted Magnetization Prepared 2 Rapid Acquisition Gradient Echoes
- BOLD:
-
Blood Oxygen Level Dependent
- CC:
-
Corpus Callosum
- DTI:
-
Diffusion Tensor Imaging
- DWI:
-
Diffusion Weighted Imaging
- FA:
-
Fractional Anisotropy
- FLAIR:
-
FLuid-Attenuated Inversion Recovery
- fMRI:
-
Functional MRI
- GE-SWI:
-
Gradient Echo Susceptibility-Weighted Imaging
- gFA:
-
Global Fractional Anisotropy
- GQI:
-
Generalized Q-sampling Imaging
- IHC:
-
Interhemispheric Connectivity
- ICBM152:
-
International Consortium for Brain Mapping 152
- HoFC:
-
Homotopic Functional Connectivity
- LEMON:
-
Leipzig Study for Mind–Body-Emotion Interactions
- LPS-2:
-
Leistungsprüfsystem 2
- LPS-2-S:
-
Leistungsprüfsystem 2 score
- MP2RAGE:
-
Magnetization Prepared 2 Rapid Acquisition
- MRI:
-
Magnetic Resonance Imaging
- p:
-
p-Value
- p-FEW:
-
Family Wise corrected p-value
- PFC:
-
Pre-Frontal cortex
- ROI:
-
Region Of Interest
- rs-IHC:
-
Resting-state Interhemispheric Connectivity
- rs-fMRI:
-
Resting state functional Magnetic Resonance Imaging
- T2*-EPI:
-
T2*-weighted gradient-echo Echo Planar Imaging
- TAP:
-
Test of Attentional Performance
- TAP-A:
-
Test of Attentional Performance—alertness
- TAP-A-NS-S:
-
Test of Attentional Performance—alertness (without signal) score
- TAP-A-S-S:
-
Test of Attentional Performance—alertness (with signal) score
- TAP-I:
-
Test of Attentional Performance—Incompatibility
- TAP-I-CS-E:
-
Test of Attentional Performance—Incompatibility (compatible signals) errors
- TAP-I-CS-S:
-
Test of Attentional Performance—Incompatibility (compatible signals) score
- TAP-I-IS-E:
-
Test of Attentional Performance—Incompatibility (incompatible stimuli) errors
- TAP-I-IS-S:
-
Test of Attentional Performance—Incompatibility (incompatible stimuli) score
- TAP-I-WS-E:
-
Test of Attentional Performance—Incompatibility (whole stimuli) errors
- TAP-I-WS-S:
-
Test of Attentional Performance—Incompatibility (whole stimuli) score
- TAP-WM:
-
Test of Attentional Performance—Working Memory
- TAP-WM-E:
-
Test of Attentional Performance—Working Memory errors
- TAP-WM-MM:
-
Test of Attentional Performance—Working Memory missed matches
- TAP-WM-S:
-
Test of Attentional Performance—Working Memory score
- TFCE:
-
Threshold Free Cluster Enhancement
- TMT:
-
Trail Making Test
- TMT-A:
-
Trail Making Test A
- TMT-A-E:
-
Trail Making Test A errors
- TMT-A-S:
-
Trail Making Test A score
- TMT-B:
-
Trail Making Test B
- TMT-B-E:
-
Trail Making Test B errors
- TMT-B-S:
-
Trail Making Test B score
- W:
-
W-value
- WM:
-
White Matter
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Conceptualization, M.P., L.C.; Methodology M.P.; Validation M.P., L.C.; Data Curation M.P., A.B., G.M.; Investigation M.P., L.C. F.M.; Writing – Original Draft, M.P., L.C., L.S.; F.M.; Writing – Review and Editing, L.S., J.S.S., Y.Q., J.P., V.P.; Supervision, L.S., J.P., P.R., Y.Q, F.M.
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The present study was conducted by exploiting the data of the freely publicly available dataset of the LEMON dataset (Babayan et al., 2019). The dataset was collected in accordance with the World Medical Association Declaration of Helsinki revised in 1989 and approved by the Ethics Committee of the University of Leipzig (reference number 154/13-ff Babayan et al., 2019).
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Porcu, M., Cocco, L., Marrosu, F. et al. Impact of corpus callosum integrity on functional interhemispheric connectivity and cognition in healthy subjects. Brain Imaging and Behavior 18, 141–158 (2024). https://doi.org/10.1007/s11682-023-00814-1
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DOI: https://doi.org/10.1007/s11682-023-00814-1