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Association of white matter volume with sleep quality: a voxel-based morphometry study

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Abstract

Many studies have focused on the gray matter volume associated with sleep quality, little is known about the relationship between white matter volume and sleep quality. Brain white structure is a crucial component in the structural neuroanatomy. Therefore, in this study, we investigated the association between white matter volume and sleep quality. Data were collected using the Pittsburgh Sleep Quality Index and voxel-based morphometry among 352 college students. Results showed that the global PSQI score was negatively associated with the white matter volume, including in the right middle occipital gyrus, the left superior temporal gyrus, the right the precentral gyrus, the left supramarginal gyrus, the left middle frontal gyrus, the left precunes, and the right superior frontal gyrus. Results also indicated that the white matter volume in specific regions negatively associated with the factor of PSQI. These specific brain regions may be replicated in brain areas related to sleep quality. In summary, we suggested that exploring brain white structure are related to sleep could help to expound the mechanisms by which sleep quality are associated with brain function, behavior and cognition, as well as potentially the networks and systems responsible for variations in sleep themselves.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This work was supported by the Research Foundation of Education Bureau of Hunan Province, China (Grant No. 18A029), Ministry of Education  Project of Humanities and Social Sciences, China (Grant No. 16XJC190002), and the Education Planning foundation of Hunan Province, China (Grant No. XJK20AXL01).

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Authors and Affiliations

  1. School of Education Science, Hunan Normal University, Changsha, 410081, China

    Youling Bai, Li Zhang, Xiaobing Cui, Dan Li & Huazhan Yin

  2. Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University, Changsha, 410081, China

    Youling Bai, Li Zhang, Xiaobing Cui, Dan Li & Huazhan Yin

  3. Department of Psychology, Hunan University of Science and Technology, Xiangtan, 411201, China

    Chengwei Liu

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  1. Youling Bai
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  2. Li Zhang
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  3. Chengwei Liu
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Contributions

YB and LZ conducted the studies, YB, LZ and CL collected and analyzed the data, YB, LZ, CL, XC, DL, and HY prepared and revised the manuscript.

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Correspondence to Dan Li or Huazhan Yin.

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Bai, Y., Zhang, L., Liu, C. et al. Association of white matter volume with sleep quality: a voxel-based morphometry study. Brain Imaging and Behavior 16, 1163–1175 (2022). https://doi.org/10.1007/s11682-021-00569-7

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