Abstract
A single nucleotide polymorphism at the LHPP gene (rs35936514) has been reported to be associated with major depressive disorder (MDD) in genome-wide association studies. We conducted a neuroimaging analysis to explore whether and which brain neural systems are affected by LHPP variation. Since LHPP variants seem to be associated with the hippocampus, we assessed the relationship between rs35936514 variation and structural–functional connectivity within a hippocampal–corticolimbic neural system implicated in MDD. A total of 122 Chinese subjects were divided into a CC homozygous group (CC genotype, n = 60) and a T allele-carrier group (CT/TT genotypes, n = 62). All subjects participated in resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) scans. Structural and functional connectivity data analyses were then performed. Compared to the CC group, the T allele-carrier group showed significantly higher fractional anisotropy (FA) values in the fornix as well as increased functional connectivity from the hippocampus to the rostral part of the anterior cingulate cortex (rACC). Moreover, a significant negative correlation between fornix FA value and hippocampus–rACC functional connectivity was identified (P < 0.05). These findings suggest that there is a relationship between rs35936514 variation and both structural and functional hippocampal–corticolimbic neural system involvement in MDD. LHPP may play an important role in the neuropathophysiology of MDD.
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Acknowledgments
This study was supported by the National Key Projects (2016YFC0906400 to X.G), the National Natural Science Foundation of China (81571311 to Y.T., 81571331 to F.W.), National Science Fund for Distinguished Young Scholars (81725005 to F.W.), National Key Research and Development Program (2016YFC1306900 to Y.T., 2016YFC0904300 to F.W.), National High Tech Development Plan (863) (2015AA020513 to F.W.), Liaoning Science and Technology Project (2015225018 to Y.T.), Liaoning Education Foundation (Pandeng Scholar to F.W.). We are grateful for the support of Shenyang Mental Health Center, Department of Radiology and Psychiatry, First Affiliated Hospital of China Medical University. We thank all the participants for their cooperation.
Funding
This study was supported by the National Key Projects (2016YFC0906400 to X.G), the National Natural Science Foundation of China (81571311 to Y.T., 81571331 to F.W.), National Science Fund for Distinguished Young Scholars (81725005 to F.W.), National Key Research and Development Program (2016YFC1306900 to Y.T., 2016YFC0904300 to F.W.), National High Tech Development Plan (863) (2015AA020513 to F.W.), Liaoning Science and Technology Project (2015225018 to Y.T.), Liaoning Education Foundation (Pandeng Scholar to F.W.).
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Lingling Cui and Xiaohong Gong are cofirst authors.
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Cui, L., Gong, X., Chang, M. et al. Association of LHPP genetic variation (rs35936514) with structural and functional connectivity of hippocampal-corticolimbic neural circuitry. Brain Imaging and Behavior 14, 1025–1033 (2020). https://doi.org/10.1007/s11682-019-00140-5
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DOI: https://doi.org/10.1007/s11682-019-00140-5