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Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder

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Abstract

Obsessive-compulsive disorder (OCD) is known as a clinically heterogeneous disorder characterized by symptom dimensions. Although substantial numbers of neuroimaging studies have demonstrated the presence of brain abnormalities in OCD, their results are controversial. The clinical heterogeneity of OCD could be one of the reasons for this. It has been hypothesized that certain brain regions contributed to the respective obsessive-compulsive dimensions. In this study, we investigated the relationship between symptom dimensions of OCD and brain morphology using voxel-based morphometry to discover the specific regions showing alterations in the respective dimensions of obsessive-compulsive symptoms. The severities of symptom dimensions in thirty-three patients with OCD were assessed using Obsessive-Compulsive Inventory-Revised (OCI-R). Along with numerous MRI studies pointing out brain abnormalities in autistic spectrum disorder (ASD) patients, a previous study reported a positive correlation between ASD traits and regional gray matter volume in the left dorsolateral prefrontal cortex and amygdala in OCD patients. We investigated the correlation between gray and white matter volumes at the whole brain level and each symptom dimension score, treating all remaining dimension scores, age, gender, and ASD traits as confounding covariates. Our results revealed a significant negative correlation between washing symptom dimension score and gray matter volume in the right thalamus and a significant negative correlation between hoarding symptom dimension score and white matter volume in the left angular gyrus. Although our result was preliminary, our findings indicated that there were specific brain regions in gray and white matter that contributed to symptom dimensions in OCD patients.

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Acknowledgments

This work was supported by Grants-in-Aid for Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture of Japan and a Grant-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan (23591733).

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Authors and Affiliations

  1. Research Center for Child Mental Development, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Motohisa Hirose, Yoshiyuki Hirano, Kenichi Asano, Haruko Miyata, Michiko Nakazato, Eiji Shimizu & Akiko Nakagawa

  2. United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, Japan

    Motohisa Hirose, Yoshiyuki Hirano, Kenichi Asano, Michiko Nakazato, Eiji Shimizu & Akiko Nakagawa

  3. Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Kiyotaka Nemoto

  4. Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Chihiro Sutoh & Eiji Shimizu

  5. Department of Regional Disaster Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

    Junko Matsumoto

  6. Department of Radiology, Chiba University Hospital, Chiba, Japan

    Koji Matsumoto & Yoshitada Masuda

  7. Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan

    Masaomi Iyo

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  1. Motohisa Hirose
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Correspondence to Yoshiyuki Hirano.

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All procedures followed were in accordance with the ethical standards of the responsible committees on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

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Figure S1

Negative liner correlations between OCI-R variables and gray matter volumes with the BDI scores as nuisance covariate ( n = 28). The negative correlation between regional gray matter volumes in the superior temporal gyrus, right thalamus, left thalamus, and left postcentral gyrus, and the washing dimension scores. Results are shown at q < 0.05, false discovery rate (FDR) corrected for multiple comparisons at the cluster level. Color bar shows t-value. Covariates are the remaining five dimension scores, gender, age, AQ scores, and BDI scores. L; left. (GIF 51 kb)

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Hirose, M., Hirano, Y., Nemoto, K. et al. Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder. Brain Imaging and Behavior 11, 1326–1333 (2017). https://doi.org/10.1007/s11682-016-9611-9

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