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Cardiorespiratory fitness and white matter integrity in Alzheimer’s disease

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Abstract

The objective of this study was to investigate the relationship between cardiorespiratory (CR) fitness and the brain’s white matter tract integrity using diffusion tensor imaging (DTI) in the Alzheimer’s disease (AD) population. We recruited older adults in the early stages of AD (n = 37; CDR = 0.5 and 1) and collected cross-sectional fitness and diffusion imaging data. We examined the association between CR fitness (peak oxygen consumption [VO2peak]) and fractional anisotropy (FA) in AD-related white matter tracts using two processing methodologies: a tract-of-interest approach and tract-based spatial statistic (TBSS). Subsequent diffusivity metrics (radial diffusivity [RD], mean diffusivity [MD], and axial diffusivity [A × D]) were also correlated with VO2peak. The tract-of-interest approach showed that higher VO2peak was associated with preserved white matter integrity as measured by increased FA in the right inferior fronto-occipital fasciculus (p = 0.035, r = 0.36). We did not find a significant correlation using TBSS, though there was a trend for a positive association between white matter integrity and higher VO2peak measures (p < 0.01 uncorrected). Our findings indicate that higher CR fitness levels in early AD participants may be related to preserved white matter integrity. However to draw stronger conclusions, further study on the relationship between fitness and white matter deterioration in AD is necessary.

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Acknowledgments

The authors wish to acknowledge Charles Henry and Michael Hulet and the rest of the Information and Telecommunication Technology Center (ITTC) staff at The University of Kansas for their support with our high performance computing.

Author Contributions

All authors contributed to analysis design, results interpretation and manuscript preparation.

Funding

Drs. Burns, Vidoni, Morris, Honea, and Rasinio Graves are supported by the University of Kansas Alzheimer’s Disease Center (P30AG035982). Supported by the National Institute on Aging (NIA) R01AG033673. Dr. Burns was also supported by grants from the NIA and NINDS (R01AG034614 & U10NS077356). Dr. Vidoni was supported in part by Frontiers: The Heartland Institute for Clinical and Translational Research (University of Kansas Medical Center’s CTSA (KL2TR000119). Dr. Honea and Rodrigo Perea are supported by a grant from NIA (K01AG035042). Work conducted in the project is supported by the National Center for Research Resources (M01RR023940), and is now at the National Center for Advancing Translational Sciences (UL1TR000001). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The KU Grayhawk Database provided contact information for potential participants.

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Authors and Affiliations

  1. KU Alzheimer’s Disease Center, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA

    R. D. Perea, E. D. Vidoni, J. K. Morris, R. S. Graves, J. M. Burns & R. A. Honea

  2. Bioengineering Program, The University of Kansas, Lawrence, KS, USA

    R. D. Perea & R. A. Honea

  3. Department of Neurology, University of Kansas School of Medicine, 4350 Shawnee Mission Parkway, Fairway, KS, 66205, USA

    R. A. Honea

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  1. R. D. Perea
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Perea, R.D., Vidoni, E.D., Morris, J.K. et al. Cardiorespiratory fitness and white matter integrity in Alzheimer’s disease. Brain Imaging and Behavior 10, 660–668 (2016). https://doi.org/10.1007/s11682-015-9431-3

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