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The associations of statin intake and the trabecular bone score and bone mineral density status in elderly Iranian individuals: a cross-sectional analysis of the Bushehr Elderly Health (BEH) program

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Abstract

Summary

In recent years, a growing interest on the impact of statin intake on bone health has emerged, although the reported results are controversial. The results of this study revealed that BMD at lumbar spine has a significant association with statin intake. However, such association appears to be weaker regarding TBS values compared to BMD. This study was performed with the aim of evaluating associations of statin intake with BMD and TBS using data from 2426 individuals aged ≥ 60 years from the second phase of the Bushehr Elderly Health (BEH) program. We found a positive association between statin and BMD at lumbar spine, whereas association between statin and TBS was detected only in the men in the final model.

Introduction

In recent years, a growing interest has been established to evaluate the impact of statin intake on bone health, although the reported results are controversial. This study aimed to evaluate the association of statin intake with bone health status according to BMD and TBS.

Methods

This cross-sectional analysis used data from the elderly Iranian individuals who participated in the Bushehr Elderly Health (BEH) program. Dual x-ray absorptiometry (DXA) device was used to evaluate the BMD at lumbar spine (L1–L4), femoral neck, and total hip, as well as TBS at lumbar spine.

Results

Among 2426 (1260 women and 1166 men) study participants, 778 were statin users. A positive significant association, irrespective of sex, was observed between statin intake and BMD at L1–L4, even after controlling for potential variables in total population (β = 0.016, p = 0.013). The mean TBS values at L1–L4 were negatively associated with statin intake in total population (β =  − 0.009, p = 0.001), while in the full adjusted model, significant positive association between TBS and statin intake was detected only in men (β = 0.013, p = 0.02).

Conclusion

The results of this study revealed that BMD at lumbar spine has a significant association with statin intake. However, such an association appears to be weaker regarding TBS values compared to BMD.

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Acknowledgements

The authors would like to illustrate their thankfulness to the researchers and staff of the Bushehr Elderly Health (BEH) program for their attentive support and contribution.

Funding

Tehran University of Medical Sciences and Endocrinology and Metabolism Research Institute.

Author information

Authors and Affiliations

  1. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran Universityof Medical Sciences, Tehran, Iran

    Samira Abbasloo, Noushin Fahimfar, Mahnaz Sanjari, Kazem Khalaji & Afshin Ostovar

  2. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No.10- Jalal -e-Ale-Ahmad Street, Chamran Highway, Tehran, 1411713119, Iran

    Hamid Reza Aghaei Meybodi

  3. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No.10- Jalal -e-Ale-Ahmad Street, Chamran Highway, Tehran, 1411713119, Iran

    Noushin Fahimfar & Bagher Larijani

  4. Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran

    Safoora Gharibzadeh

  5. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Gita Shafiee & Ramin Heshmat

  6. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

    Iraj Nabipour

  7. The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

    Amirhossein Darabi

  8. Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

    Mohammad Moein Abbasloo

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  1. Samira Abbasloo
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  2. Hamid Reza Aghaei Meybodi
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Contributions

SA contributed to the literature review, conception and design, and drafting of the manuscript. HRA contributed to the study design, supervised the project, interpreted the results and revised the manuscript critically. NF supervised the project, contributed to the study design, statistical analysis and interpretation of the results and revised the manuscript critically. RH and SGh offered technical advice for statistical analysis, interpreted the results and revised the manuscript critically. MS, KKh, GSh, AHD, and MMA contributed to the literature review, data cleaning, statistical analysis, drafting the manuscript, and reviewed the final manuscript. IN, BL and AO contributed to conception and design, acquisition of data, certified the protocols of the study, and made critically revised the manuscript. All authors finally approved the manuscript to be published.

Corresponding authors

Correspondence to Hamid Reza Aghaei Meybodi or Noushin Fahimfar.

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Research Ethics Committee of Bushehr University of Medical Sciences and Endocrinology and Metabolism Research Institute affiliated to Tehran University of Medical Sciences approved the protocol of the study (Ethical Code: IR.TUMS.MEDICINE.REC.1398.354).

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All participants signed a written informed consent earlier taking part in the study.

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Informed consent was obtained from all individual participants included in the study.

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Hamid Reza Aghaei Meybodi and Noushin Fahimfar contributed the corresponding authorship.

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Abbasloo, S., Aghaei Meybodi, H.R., Fahimfar, N. et al. The associations of statin intake and the trabecular bone score and bone mineral density status in elderly Iranian individuals: a cross-sectional analysis of the Bushehr Elderly Health (BEH) program. Arch Osteoporos 16, 144 (2021). https://doi.org/10.1007/s11657-021-00991-w

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