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Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction

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Abstract

Objective

To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan (WSY-1075) in a detrusor underactivity rat model.

Methods

Rats were randomly allocated to three groups: shamoperated (control), bladder outlet obstruction-induced detrusor underactivity (BOO-DU), and BOO-DU with WSY-1075 (WSY) groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks prior to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders.

Results

Compared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure (P<0.05). WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group (P<0.05).

Conclusion

WSY-1075 had beneficial effect on prevention of BOO-DU.

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Authors and Affiliations

  1. Department of Urology, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea

    Jin-Woo Jung, Mun Su Chung & Byung Il Yoon

  2. Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneungsi, Gangwon-do, Republic of Korea

    Jin-Woo Jung

  3. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Seung Hwan Jeon, Woong Jin Bae, Su Jin Kim, Sae Woong Choi, U. Syn Ha & Sae Woong Kim

  4. Catholic Integrative Medicine Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Woong Jin Bae & Sae Woong Kim

  5. Korea Bio Medical Science Institute, Seoul, Republic of Korea

    Sung Yeoun Hwang

Authors
  1. Jin-Woo Jung
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  2. Seung Hwan Jeon
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  3. Woong Jin Bae
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  4. Su Jin Kim
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  5. Mun Su Chung
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  7. Sae Woong Choi
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  8. U. Syn Ha
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  10. Sae Woong Kim
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Corresponding author

Correspondence to Sae Woong Kim.

Additional information

Supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (No. HI15C0099)

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Jung, JW., Jeon, S.H., Bae, W.J. et al. Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction. Chin. J. Integr. Med. 24, 670–675 (2018). https://doi.org/10.1007/s11655-017-2970-1

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  • DOI: https://doi.org/10.1007/s11655-017-2970-1

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