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Sodium Tanshinone II A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials

  • Evidence-Based Integrative Medicine
  • Published:
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Abstract

Objective

To systematically evaluate the effectiveness and safety of Sodium Tanshinone II A Sulfonate Injection (STS) as one adjuvant therapy for treating unstable angina pectoris (UAP).

Methods

Randomized controlled trials (RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Wanfang Database, the Chinese Biomedical Literature Database (CBM), Web of Science, the Cochrane Library, Embase, and PubMed, which from inception to January, 2016. The Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the metaanalysis.

Results

The results showed that 17 RCTs involving 1,372 patients were included. The meta-analysis indicated that the combined use of STS and Western medicine (WM) in the treatment of UAP can obviously improve the total effective rate [risk ratio (RR)=1.31, 95% confidence interval (CI) (1.24,1.39), P<0.0001], and the total effective rate of electrocardiogram [RR=1.43, 95% CI (1.30,1.56), P<0.0001], decrease the level of CRP [mean difference (MD)=–3.06, 95%CI (–3.85,–2.27), P<0.00001], fibrinogen [MD=–1.03, 95% CI (–1.16,–0.89), P<0.00001], and whole blood high shear viscosity [MD=–0.70, 95% CI (–0.92,–0.49), P<0.00001]. Additionally, the occurrence of adverse drug reaction of the experimental group was significantly higher than that of the control group [RR=3.57, 95% CI (1.28, 9.94), P<0.05].

Conclusions

Compared with WM, the combined use of STS was more effective.

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Authors and Affiliations

  1. Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China

    Di Tan, Jia-rui Wu, Xiao-meng Zhang, Shi Liu & Bing Zhang

Authors
  1. Di Tan
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  2. Jia-rui Wu
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  3. Xiao-meng Zhang
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  4. Shi Liu
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  5. Bing Zhang
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Corresponding author

Correspondence to Jia-rui Wu.

Additional information

Supported by the National Natural Science Foundation of China (No. 81473547 and No. 81673829)

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Tan, D., Wu, Jr., Zhang, Xm. et al. Sodium Tanshinone II A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials. Chin. J. Integr. Med. 24, 156–160 (2018). https://doi.org/10.1007/s11655-017-2424-x

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  • DOI: https://doi.org/10.1007/s11655-017-2424-x

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