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Clinical study on Kangquan Recipe (康泉方) for benign prostatic hyperplasia patients: A randomized controlled trial

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Abstract

Objective

To observe the effectiveness and safety of Kangquan Recipe (康泉方, KQR) for benign prostatic hyperplasia (BPH) patients.

Methods

One hundred and six BPH patients were randomly assigned to the treatment group (53 cases) and the control group (53 cases) according to a random number table. The treatment group was given KQR orally; the control group was given cernilton orally. After 24-week treatment, the clinical effect and safety were evaluated using the International Prostatic Symptom Score (I-PSS), quality of life (QOL), maximum flow rate (Qmax), average flow rate (Qave), residual urine volume (RUV), total prostatic volume (TPV), etc.

Results

After treatment, the score of I-PSS was decreased from 16.9±5.6 to 12.5±4.6 in the treatment group, significantly lower compared with the control group; the levels of Qmax and Qave were from 10.9±3.5 to 15.6±4.5 and 5.4±2.1 to 7.3±2.5 (mL/s) in the treatment group, significantly higher compared with the control group; the levels of RUV and TPV were from 70.8±28.2 to 35.2±21.8 and 37.2±16.9 to 30.1±10.8 (mL) in the treatment group, significantly lower compared with the control group (all P<0.05). The incidence rate of adverse reaction was similar between the two groups (P>0.05).

Conclusion

KQR is effective and safe for the treatment of BPH.

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References

  1. Ministry of Health, P. R. China. Guidance on principle of pre-clinical research on new drug. Beijing: People’s Medical Publishing House; 1993:101–103.

    Google Scholar 

  2. Paolone DR. Benign prostatic hyperplasia. Clin Geriatr Med 2010;26:223–239.

    Article  PubMed  Google Scholar 

  3. AUA Practice Guidelines Committee. AUA guideline on management of benign prostatic hyperplasia (2003). Chapter 1: Diagnosis and treatment recommendations. Urology 2003;170:530–547.

    Article  Google Scholar 

  4. Huang YP, Wu JF. On relation of collaterals diseases in TCM and benign prostatic hyperplasia. China J Tradit Chin Med Pharm (Chin) 2006;21:45–46.

    Google Scholar 

  5. Yang Y, Gu FL. The opinion recommended by the fifth session of the International Advisory Committee on benign prostatic hyperplasia in the International Scientific Committee: the evaluation and treatment of elderly men with lower urinary tract symptoms. Chin J Urol (Chin) 2001;22:564–570.

    Google Scholar 

  6. Roehrborn CG. Male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Med Clin North Am 2011;95:87–100.

    Article  PubMed  Google Scholar 

  7. Huang YP, Du J, Hong ZF, Chen ZQ, Zhao JY, Li TJ, et al. Effect of Kangquan Recipe on apoptosis regulatory genes bax and bcl-2mRNA in prostate of rats. Chin J Integr Tradit West Med (Chin) 2007;27:711–714.

    Google Scholar 

  8. Huang YP, Du J, Hong ZF, Chen ZQ, Zhao JY, Li TJ, et al. Effect of Kangquan Recipe on basic fibroblast growth factor in prostate of rats. Chin J Integr tradit West Med (Chin) 2008;28:711–714.

    Google Scholar 

  9. Huang YP, Du J, Hong ZF, Chen ZQ, Wu JF, Zhao JY, et al. Effects of Kangquan Recipe on sex steroids and cell proliferation in rats with benign prostatic hyperplasia. Chin J Integr Med 2009;15:268–272.

    Article  Google Scholar 

  10. Hong ZF, Lin JM, Zhong XY, Li Y, Zhou JH, Xu W. et al. Qianliening Capsule inhibits human prostate cell growth via induction of mitochondrion-dependent cell apoptosis. Chin J Integr Med 2012;18:824–830

    Article  PubMed  Google Scholar 

  11. Li YF, Tang LP, He RR, Xu Z, He QQ, Xiang FJ, et al. Anthocyanins extract from bilberry enhances the therapeutic effect of pollen of Brassica napus L. on stress-provoked benign prostatic hyperplasia in restrained mice. J Functi Foods 2013;5:1357–1365.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Traditional Chinese Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian Province, 361004, China

    Yuan-peng Huang  (黄源鹏), Yan-hui Wen  (温艳晖), Geng-hui Wu  (吴耿惠), Shang-wen Xu  (徐尚文) & A-xiang Peng  (彭阿香)

  2. Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350108, China

    Yuan-peng Huang  (黄源鹏) & Zhen-feng Hong  (洪振丰)

Authors
  1. Yuan-peng Huang  (黄源鹏)
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  2. Yan-hui Wen  (温艳晖)
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  3. Geng-hui Wu  (吴耿惠)
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  4. Zhen-feng Hong  (洪振丰)
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  5. Shang-wen Xu  (徐尚文)
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  6. A-xiang Peng  (彭阿香)
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Corresponding author

Correspondence to Yuan-peng Huang  (黄源鹏).

Additional information

Supported by the Foundation of Science and Technology Department of Xiamen (No. 3502Z20084014), the Foundation of Key Projects from Science and Technology Department of Fujian Province (No. 2012D064), and the Foundation of Traditional Chinese Medicine of Fujian Province (No. wst201208)

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Huang, Yp., Wen, Yh., Wu, Gh. et al. Clinical study on Kangquan Recipe (康泉方) for benign prostatic hyperplasia patients: A randomized controlled trial. Chin. J. Integr. Med. 20, 949–954 (2014). https://doi.org/10.1007/s11655-014-2021-1

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  • DOI: https://doi.org/10.1007/s11655-014-2021-1

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