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The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine

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Abstract

Objective

To investigated the involvement of pulmonary function impairment in ulcerative colitis (UC), to explore a scientific basis for the Chinese medicine (CM) theory of exterior-interior correlation between Lung (Fei) and Large intestine (Dachang).

Methods

Totally 120 patients with a diagnosis of UC were recruited and the demographics, clinical data, and blood samples were collected. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) concentrations were measured. Every patient accepted pulmonary function test and took chest radiograph (CXR).>

Results

Pulmonary function abnormalities were present in 72 of 120 patients. The median (interquartile range) vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), carbon monoxide diffusion capacity (DLCO) of lung, total lung capacity (TLC) and functional residual volume (FRV) were decreased in distal UC and pancolitis compared with ulcerative prochitis (P <0.0005). Male patients had increased VC, FEV1/FVC, and residual volume (RV)/TLC compared with female (P <0.0005), but decreased DLCO and carbon monoxide iffusion capacity (KCO) of lung/alveolar ventilation (P <0.0005). Age was strongly correlated with RV (Spearman rank correlation coefficient (rs)=−0.57,P <0.0001), and RV/TLC (rs=0.48,P<0.0001). Age was also correlated with FEV1/FVC (rs=−0.29, P=0.001), forced expiratory flow in 75% vital capacity (FEF75%, rs=−0.20, P=0.03), DLCO (rs=−0.21, P=0.02), TLC (rs=−0.25, P=0.006), and FRV (rs=−0.28, P=0.002). The course of disease was correlated with FEF75% (rs=−0.18, P=0.049) and KCO (rs=−0.19, P=0.036). Chest radiograph abnormalities were presented in 38 of 120. Pulmonary symptoms were presented in 10 of 120. Other extraintestinal complications were presented in 21 of 120.

Conclusions

Pulmonary function impairment was more frequently than other extraintestinal complications in UC patients, which may be affected by sex, age, extent and course of disease. These results may be a scientific basis for the theory of exterior-interior correlation between Lung and Large intestine.

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Acknowledgment

All study design, analysis and manuscript preparation were carried out independently in Dongzhimen Hospital, China. We thank all the clinical staff of Dongzhimen Hospital involved in the care of the patients in this study.

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Authors and Affiliations

  1. Department of Gastroenterology, the Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100029, China

    Jian-yun Wang  (王建云)

  2. Department of Gastroenterology, Dongzhimen Hospital, Beijing, 100700, China

    Xin-yue Wang  (王新月), Hui-yi Sun  (孙慧怡), Da-ming Liu  (刘大铭) & Wen Zhang  (张 雯)

  3. Department of Respiratory, Dongzhimen Hospital, Beijing, 100700, China

    Hua-yang Wu  (吴华阳)

  4. Lung Function Laboratory, Dongzhimen Hospital, Beijing, 100700, China

    Chen-xi Jin  (金晨曦)

  5. Deparment of Vasculocardiology, Dongzhimen Hospital, Beijing, 100700, China

    Shuo-ren Wang  (王硕仁)

Authors
  1. Jian-yun Wang  (王建云)
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  2. Xin-yue Wang  (王新月)
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  3. Hua-yang Wu  (吴华阳)
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  4. Hui-yi Sun  (孙慧怡)
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  5. Da-ming Liu  (刘大铭)
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  6. Wen Zhang  (张 雯)
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  7. Chen-xi Jin  (金晨曦)
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  8. Shuo-ren Wang  (王硕仁)
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Corresponding author

Correspondence to Xin-yue Wang  (王新月).

Additional information

Supported by the National Basic Research Program, Ministry of Science and Technology, China (No. 2009CB522705)

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Wang, Jy., Wang, Xy., Wu, Hy. et al. The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine. Chin. J. Integr. Med. 22, 894–901 (2016). https://doi.org/10.1007/s11655-014-1842-2

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  • DOI: https://doi.org/10.1007/s11655-014-1842-2

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