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Tumor Deposit Is an Independent Factor Predicting Early Recurrence and Poor Prognosis in Gastric Cancer

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Background

Accurate prognostic estimation is crucial; however, the prognostic value of tumor deposits in gastric cancer remains controversial. This study aimed to investigate their prognostic significance.

Methods

Clinicopathological and prognostic data of 1012 gastric cancer patients who underwent R0 or R1 surgery from 2010 to 2017 at the Osaka International Cancer Institute were retrospectively reviewed.

Results

Overall, 6.3% patients had tumor deposits, which were associated with Borrmann type, surgical procedure, type of gastrectomy, extent of lymphadenectomy, tumor size, histology, pT, pN, pM, pStage, lymphatic invasion, vascular invasion, preoperative chemotherapy, and postoperative chemotherapy. Tumor deposit-positive patients had worse 5-year disease-free survival (32.60% vs. 92.45%) and overall survival (41.22% vs. 89.37%) than tumor deposit-negative patients. Subgroup analysis regarding pStage II–III also showed significant differences between patients with and without tumor deposits for 5-year disease-free survival (34.15% vs. 80.98%) and overall survival (43.17% vs. 75.78%). Multivariable analysis showed that older age, undifferentiated histology, deeper tumor invasion, lymph node metastasis, distant metastasis, and presence of tumor deposits were significantly correlated with early tumor recurrence and shorter survival time; these factors were identified as independent prognostic factors. The 5-year disease-free survival of tumor deposit-positive patients was significantly worse than that of patients in the pStage III group and comparable to that of patients in the pT4, pN3, and pM1 groups. The 5-year overall survival of tumor deposit-positive patients was comparable to that of the pT4, pN3, pM1, and pStage III groups.

Conclusions

Tumor deposits are strong and independent predictors of tumor recurrence and poor survival.

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Data Availability

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Osaka International Cancer Institute, 3-1-69 Otemae, Tyuo-Ward, Osaka City, Osaka-Prefecture, Japan

    Kaoru Fujikawa, Takeshi Omori, Naoki Shinno, Hisashi Hara, Masaaki Yamamoto, Masayoshi Yasui, Chu Matsuda, Hiroshi Wada, Junichi Nishimura, Naotsugu Haraguchi, Hirofumi Akita, Masayuki Ohue & Hiroshi Miyata

Authors
  1. Kaoru Fujikawa
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  2. Takeshi Omori
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Contributions

All the authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Kaoru Fujikawa and Takeshi Omori. The first draft of the manuscript was written by Kaoru Fujikawa, and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.

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Correspondence to Takeshi Omori.

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Fujikawa, K., Omori, T., Shinno, N. et al. Tumor Deposit Is an Independent Factor Predicting Early Recurrence and Poor Prognosis in Gastric Cancer. J Gastrointest Surg 27, 1336–1344 (2023). https://doi.org/10.1007/s11605-023-05668-y

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  • DOI: https://doi.org/10.1007/s11605-023-05668-y

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