Abstract
Purpose
The most common surgery for ulcerative colitis (UC) is the staged restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). On occasion, an emergent first-stage subtotal colectomy must be performed. The purpose of this study was to compare rates of postoperative complications in three-stage IPAA patients who underwent emergent vs non-emergent first-stage subtotal colectomies in the subsequent staged procedures.
Methods
This was a retrospective chart review conducted at a single tertiary care inflammatory bowel disease (IBD) center. All UC or IBD-Unspecified patients who underwent a three-stage IPAA between 2008 and 2017 were identified. Emergent surgery was defined as that performed on an inpatient who had perforation, toxic megacolon, uncontrolled hemorrhage, or septic shock. The primary outcomes were the presence of anastomotic leak, obstruction, bleeding, and the need for reoperation for each within a 6-month postoperative period of the second (RPC with IPAA and DLI) and third surgical stages (ileostomy reversal).
Results
A total of 342 patients underwent a three-stage IPAA, of which 30 (9.4%) had emergent first-stage operations. Patients who underwent an emergent STC were more likely to have a post-operative anastomotic leak and need an additional procedure following the subsequent second and third-staged operations on both univariate and multivariate analysis (p < 0.05). No difference was found for obstruction, wound infection, intra-abdominal abscess, or bleeding (p > 0.05).
Conclusion
Three-stage IPAA patients with emergent first-stage subtotal colectomies were more likely to have a post-operative anastomotic leak and need an additional procedure for a leak following the subsequent second- and third-stage operations.
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Data Availability
The datasets generated during the current study are available from the corresponding author on reasonable request.
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Each author has provided substantial contributions to the conception of this study, including data collection and analysis and manuscript drafting and revising. The final draft of this manuscript has been approved by all authors to be published.
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Michael C. Plietz MD: none declared.
Marine Coste MD: none declared.
Jeremy Miller MD: none declared.
Maia Kayal MD: none declared.
Kathryn Ely Pierce Chuquin MD: none declared.
Anam Rizvi MD: none declared.
Venu Bangla MD: none declared.
Marla C. Dubinsky: none declared.
Sergey Khaitov MD: none declared.
Patricia A. Sylla MD: consulting fees for Medtronic, Ethicon, Stryker, Safeheal, and RedDress.
Alexander J. Greenstein MD: payment for Takeda Lecture.
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Poster Presentation: American College of Surgeons Clinical Congress 2020.
Abstract published in Journal of American College of Surgeons October 2020 Scientific Forum Abstracts.
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Plietz, M.C., Coste, M., Miller, J. et al. Emergent Subtotal Colectomies Have Higher Leak Rates in Subsequent J-Pouch Stages. J Gastrointest Surg 27, 760–765 (2023). https://doi.org/10.1007/s11605-023-05631-x
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DOI: https://doi.org/10.1007/s11605-023-05631-x