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Decreasing Colectomy Rates in Ulcerative Colitis in the Past Decade: Improved Disease Control?

  • SSAT Plenary Presentation
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Ulcerative colitis (UC) is primarily medically managed. Colectomy is required in patients with refractory disease or severe complications. Older studies have reported 20-year colectomy rates of over 50%, but recent studies showed decreased rates to 15%. Temporal trends in the use of colectomy in UC over the past decade (when the use of biologics has become widespread) are lacking.

Methods

Case-control study using the National Inpatient Sample database for years of 2007, 2010, 2013, and 2016 was performed. The primary outcome was determining the temporal trends in the use of colectomy in hospitalized patients with UC. Secondary outcomes were determining the total number of admissions for patients with UC and associated trend in inflation-adjusted hospital costs, charge, and length of hospital stay (LOS). Multivariate regression analyses were used to adjust for other co-variables.

Results

443,043 patients with UC were identified, of which 19,208 underwent colectomy in the study period. The mean patient age was 52 years, and 47% were female. Five percent of hospitalized patients with UC underwent colectomy in 2007, while 2.7% of patients with UC had colectomy in 2016, representing a 46% decrease in colectomies in hospitalized patients in the study period. Patients with UC displayed adjusted odds of colectomy of 0.51 (p < 0.01), adjusted additional mean hospital costs decrease by − $2898 (p < 0.01), hospital charges increase by $26,554 (p < 0.01), LOS decrease by − 2.2 days (p < 0.01) in 2016 compared to 2007.

Conclusion

The odds of colectomy in UC patients decreased significantly over the past decade, likely secondary to improved medical care.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA

    Hassan Ghoz, Sanne A. Hoogenboom, Bhaumik Brahmbhatt, John Cangemi & Paul T. Kröner

  2. Department of Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA

    Alex Kesler

  3. Department of Medicine, Universidad Europea de Madrid, Madrid, Spain

    Filippo Gavi

Authors
  1. Hassan Ghoz
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  2. Alex Kesler
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  3. Sanne A. Hoogenboom
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  4. Filippo Gavi
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  5. Bhaumik Brahmbhatt
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  6. John Cangemi
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  7. Paul T. Kröner
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Contributions

Hassan Ghoz drafted the manuscript. Alex Kesler, Sanne A. Hoogenboom, Filippo Gavi, Bhaumik Brahmbhatt, and John Cangemi have assisted in formulating the methodology and reviewing the manuscript; Paul T. Kröner generated the project’s core hypothesis, gathered and analyzed the data, supervised, and reviewed the manuscript.

Corresponding author

Correspondence to Paul T. Kröner.

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The authors declare that they have no conflict of interest.

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This research was presented as an SSAT Plenary Session at DDW 2019 in San Diego, CA.

Appendix

Appendix

Table 5 Bed size categories based on hospital beds
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Ghoz, H., Kesler, A., Hoogenboom, S.A. et al. Decreasing Colectomy Rates in Ulcerative Colitis in the Past Decade: Improved Disease Control?. J Gastrointest Surg 24, 270–277 (2020). https://doi.org/10.1007/s11605-019-04474-9

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