Abstract
Background
Anastomotic leak is one of the most feared complications of gastrointestinal surgery. Surgeons routinely perform a diverting loop ileostomy (DLI) to protect high-risk colo-rectal anastomoses.
Study Design
The NSQIP database was queried from 2012 to 2013 for patients undergoing open ileo-colic resection with and without a DLI. The primary outcome was the development of any anastomotic leak—including those managed operatively and non-operatively. Secondary outcomes included overall complication rate, return to the OR, readmission, and 30-day mortality.
Results
Four thousand one hundred fifty-nine patients underwent open ileo-colic resection during the study period. One hundred eighty-six (4.5 %) underwent a DLI. Factors associated with the addition of a DLI included emergency surgery, pre-operative sepsis, and IBD. There were 197 anastomotic leaks (4.7 %) with 100 patients requiring reoperation (2.4 %). DLI was associated with a decrease in anastomotic leaks requiring reoperation (DLI vs no DLI: 0 (0 %) vs 100 (2.5 %); p = 0.02) and with increased readmission (OR 1.93; 95 % CI 1.30–2.85; p = 0.001).
Conclusion
DLI is rarely used for open ileo-colic resection. There were no serious leaks requiring reoperation in the DLI group. A DLI was associated with an almost two-fold increase in the odds of readmission. Surgeons must weigh the reduction in serious leak rate with postoperative morbidity when considering a DLI for open ileo-colic resection.
Similar content being viewed by others
References
Matthiessen P, Hallbook O, Rutegard J, Simert G, Sjodahl R. Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: A randomized multicenter trial. Ann Surg. 2007;246(2):207-214
Huser N, Michalski CW, Erkan M, et al. Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery. Ann Surg. 2008;248(1):52-60
Chude GG, Rayate NV, Patris V, et al. Defunctioning loop ileostomy with low anterior resection for distal rectal cancer: Should we make an ileostomy as a routine procedure? A prospective randomized study. Hepatogastroenterology. 2008;55(86-87):1562-1567
Weston-Petrides GK, Lovegrove RE, Tilney HS, et al. Comparison of outcomes after restorative proctocolectomy with or without defunctioning ileostomy. Arch Surg. 2008;143(4):406-412
Tan WS, Tang CL, Shi L, Eu KW. Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer. Br J Surg. 2009;96(5):462-472
Giannakopoulos GF, Veenhof AA, van der Peet DL, Sietses C, Meijerink WJ, Cuesta MA. Morbidity and complications of protective loop ileostomy. Colorectal Dis. 2009;11(6):609-612
Ulrich AB, Seiler C, Rahbari N, Weitz J, Buchler MW. Diverting stoma after low anterior resection: More arguments in favor. Dis Colon Rectum. 2009;52(3):412-418
Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA. Anastomotic leaks after intestinal anastomosis: It’s later than you think. Ann Surg. 2007;245(2):254-258
Veyrie N, Ata T, Muscari F, et al. Anastomotic leakage after elective right versus left colectomy for cancer: Prevalence and independent risk factors. J Am Coll Surg. 2007;205(6):785-793
Midura EF, Hanseman D, Davis BR, et al. Risk factors and consequences of anastomotic leak after colectomy: A national analysis. Dis Colon Rectum. 2015;58(3):333-338
Law WL, Chu KW. Anterior resection for rectal cancer with mesorectal excision: A prospective evaluation of 622 patients. Ann Surg. 2004;240(2):260-268
Telem DA, Chin EH, Nguyen SQ, Divino CM. Risk factors for anastomotic leak following colorectal surgery: A case-control study. Arch Surg. 2010;145(4):371-6; discussion 376
Bertelsen CA, Andreasen AH, Jorgensen T, Harling H, Danish Colorectal Cancer Group. Anastomotic leakage after anterior resection for rectal cancer: Risk factors. Colorectal Dis. 2010;12(1):37-43
American College of Surgeons. User guide for the 2013 ACS NSQIP participant data use file. https://Www.facs.org/~/media/files/quality%20programs/nsqip/2013_acs_nsqip_puf_user_guide.ashx. Accessed November 23, 2015.
Fink AS, Campbell DA Jr, Mentzer RM Jr, et al. The national surgical quality improvement program in non-veterans administration hospitals: Initial demonstration of feasibility. Ann Surg. 2002;236(3):344-53
Golub R, Golub RW, Cantu R Jr, Stein HD. A multivariate analysis of factors contributing to leakage of intestinal anastomoses. J Am Coll Surg. 1997;184(4):364-372
Konishi T, Watanabe T, Kishimoto J, Nagawa H. Risk factors for anastomotic leakage after surgery for colorectal cancer: Results of prospective surveillance. J Am Coll Surg. 2006;202(3):439-444
Suding P, Jensen E, Abramson MA, Itani K, Wilson SE. Definitive risk factors for anastomotic leaks in elective open colorectal resection. Arch Surg. 2008;143(9):907-11; discussion 911-2
Sorensen LT, Jorgensen T, Kirkeby LT, Skovdal J, Vennits B, Wille-Jorgensen P. Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg. 1999;86(7):927-931
Chun LJ, Haigh PI, Tam MS, Abbas MA. Defunctioning loop ileostomy for pelvic anastomoses: Predictors of morbidity and nonclosure. Dis Colon Rectum. 2012;55(2):167-174
Messaris E, Sehgal R, Deiling S, et al. Dehydration is the most common indication for readmission after diverting ileostomy creation. Dis Colon Rectum. 2012;55(2):175-180
Author Contribution
All authors have provided substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work, drafted the work or revised it critically for important intellectual content, approved the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Support
Departmental
Conflict of Interest
The authors declare that they have no conflict of interest.
Additional information
Presented as a poster presentation at the 2016 Digestive Disease Week in San Diego, CA, May 21–24, 2016.
Rights and permissions
About this article
Cite this article
Hawkins, A.T., Dharmarajan, S., Wells, K.K. et al. Does Diverting Loop Ileostomy Improve Outcomes Following Open Ileo-Colic Anastomoses? A Nationwide Analysis. J Gastrointest Surg 20, 1738–1743 (2016). https://doi.org/10.1007/s11605-016-3230-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11605-016-3230-z