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Anatomic Versus Nonanatomic Hepatectomy for a Solitary Hepatocellular Carcinoma

A Case-Controlled Study with Propensity Score Matching

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

It remains controversial whether anatomical resection (AR) improves the prognosis for hepatocellular carcinoma (HCC) or not. To our knowledge, there have been a few well-matched studies about this issue. The aim of the present study was to compare the recurrence-free survival of AR versus nonanatomical resection (NAR) for a solitary HCC using propensity score matching.

Methods

The present study included 236 patients who had a solitary HCC without macroscopic vessel thrombosis. Those patients were divided into AR (n = 139) and NAR (n = 97) groups. A propensity score matching was performed to minimize the effect of potential confounders.

Results

Sixty-four patients from each group were matched. Preoperative confounding factors were balanced between the two groups. The median recurrence-free survival times in the AR and NAR groups were 33.8 and 30.8 months, respectively (P = 0.520). There were no significant differences in the intrahepatic recurrence pattern (P = 0.097). Operative procedure was not a significant risk factor for recurrence in both uni- and multivariate analyses.

Conclusions

This case-matching study using a propensity score shows that there is no superiority of AR to NAR relevant to the recurrence-free survival in patients with a single HCC.

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Authors and Affiliations

  1. Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan

    Yukiyasu Okamura, Takaaki Ito, Teiichi Sugiura & Katsuhiko Uesaka

  2. Clinical Trial Coordination Office, Shizuoka Cancer Center Hospital, Shizuoka, Japan

    Keita Mori

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  1. Yukiyasu Okamura
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  2. Takaaki Ito
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  3. Teiichi Sugiura
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  4. Keita Mori
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  5. Katsuhiko Uesaka
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Correspondence to Yukiyasu Okamura.

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Okamura, Y., Ito, T., Sugiura, T. et al. Anatomic Versus Nonanatomic Hepatectomy for a Solitary Hepatocellular Carcinoma. J Gastrointest Surg 18, 1994–2002 (2014). https://doi.org/10.1007/s11605-014-2646-6

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  • DOI: https://doi.org/10.1007/s11605-014-2646-6

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