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Radiomics in medical imaging: pitfalls and challenges in clinical management

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Background

Radiomics and radiogenomics are two words that recur often in language of radiologists, nuclear doctors and medical physicists especially in oncology field. Radiomics is the technique of medical images analysis to extract quantitative data that are not detected by human eye.

Methods

This article is a narrative review on Radiomics in Medical Imaging. In particular, the review exposes the process, the limitations related to radiomics, and future prospects are discussed.

Results

Several studies showed that radiomics is very promising. However, there were some critical issues: poor standardization and generalization of radiomics results, data-quality control, repeatability, reproducibility, database balancing and issues related to model overfitting.

Conclusions

Radiomics procedure should made considered all pitfalls and challenges to obtain robust and reproducible results that could be generalized in other patients cohort.

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Availability of data and materials

Data are available at https://zenodo.org/record/6383898#.Yj15W-fMK3A

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Authors and Affiliations

  1. Medical Oncology Division, Igea SpA, Naples, Italy

    Roberta Fusco

  2. Division of Radiology, “Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli”, Naples, Italy

    Vincenza Granata

  3. Department of Radiology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

    Giulia Grazzini, Silvia Pradella & Vittorio Miele

  4. Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, via della Signora 2, 20122, Milan, Italy

    Giulia Grazzini, Silvia Pradella, Pierpaolo Palumbo, Federico Bruno, Roberta Grassi, Roberto Grassi, Vittorio Miele & Antonio Barile

  5. Department of Clinical Special and Dental Sciences, School of Radiology, University Politecnica delle Marche, Ancona, Italy

    Alessandra Borgheresi, Alessandra Bruno & Andrea Giovagnoni

  6. Department of Diagnostic Imaging, Area of Cardiovascular and Interventional Imaging, Abruzzo Health Unit 1, 67100, L’Aquila, Italy

    Pierpaolo Palumbo

  7. Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, 67100, L’Aquila, Italy

    Federico Bruno & Antonio Barile

  8. Division of Radiology, “Università Degli Studi della Campania Luigi Vanvitelli”, Naples, Italy

    Roberta Grassi & Roberto Grassi

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Fusco, R., Granata, V., Grazzini, G. et al. Radiomics in medical imaging: pitfalls and challenges in clinical management. Jpn J Radiol 40, 919–929 (2022). https://doi.org/10.1007/s11604-022-01271-4

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