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In vitro evaluation of radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) with static imaging and flow model

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Abstract

Purpose

To evaluate the radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) under X-ray imaging.

Materials and methods

SAP-MS were suspended in contrast material (iodixanol) and the diameter change was assessed. The diameter of contrast-loaded SAP-MS in saline was measured sequentially. Radiography of the contrast-loaded SAP-MS was evaluated as radiopacity by contrast-to-noise ratio and visibility by multiple reader scoring. Under digital subtraction angiography, contrast-loaded SAP-MS were injected into a flow model. The flow speed was 1–10 cm/s, and images were acquired at 1–7.5 frames per second using a pulse width of 10–85 ms. Images were assessed by multiple reader scoring.

Results

The diameter of SAP-MS increased to 4.0–5.0 times its original size for approximately 15 min. The diameter of contrast-loaded SAP-MS in saline further increased by 10–30% within several minutes and returned to the previous size. Radiopacity and visibility of contrast-loaded SAP-MS decreased in 30 min after mixing with saline. Visibility was better with slow flow speed and narrow pulse width.

Conclusion

For effective observation, contrast-loaded SAP-MS should be kept in non-diluted contrast material until use. The conditions of slower flow and use of a narrow pulse width are recommended.

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Funding

This study was not supported by any funding.

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Authors and Affiliations

  1. Department of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan

    Akiko Narita, Takahiro Yamamoto, Shuji Ikeda, Yuichiro Izumi, Akira Kitagawa, Makiyo Hagihara, Toyohiro Ota, Tsuneo Ishiguchi & Kojiro Suzuki

  2. Department of Radiological Technology, Aichi Medical University Hospital, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan

    Mansaku Takeda

  3. Biostatistics Center, Graduate School of Medicine, Kurume University, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan

    Kenta Murotani

Authors
  1. Akiko Narita
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  2. Takahiro Yamamoto
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  3. Shuji Ikeda
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  4. Yuichiro Izumi
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  5. Akira Kitagawa
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  9. Toyohiro Ota
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Corresponding author

Correspondence to Akiko Narita.

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Narita, A., Yamamoto, T., Ikeda, S. et al. In vitro evaluation of radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) with static imaging and flow model. Jpn J Radiol 37, 710–718 (2019). https://doi.org/10.1007/s11604-019-00863-x

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  • DOI: https://doi.org/10.1007/s11604-019-00863-x

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