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Computed tomographic colonography with a reduced dose of laxative using a novel barium sulfate contrast agent in Japan

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Abstract

Purpose

To test the tagging efficacy, patient acceptability, and accuracy of computed tomographic colonography (CTC) with a reduced dose of laxative using a novel barium sulfate (BaSO4) contrast agent.

Materials and methods

CTC followed by optical colonoscopy (OC) was performed on 73 patients with positive results in fecal occult blood tests. They were administrated a BaSO4 suspension and a magnesium citrate solution for bowel preparation. Patients completed a questionnaire about the acceptability of bowel preparation. Tagging efficacy was estimated using a novel categorization system, which classified all segments into 8 categories. The accuracy of detecting protruded lesions ≥ 6 mm was calculated from the comparison of CTC and OC results, using the latter as a reference standard.

Results

Tagging efficacy was good in 77.3% of colonic segments where residue was observed. The acceptability of bowel preparation for CTC was significantly higher than that for OC. The sensitivity, specificity, and positive and negative predictive values were 0.778, 0.945, 0.824, and 0.929, respectively. All lesions ≥ 7 mm were successfully detected by CTC.

Conclusion

CTC with a reduced dose of laxative using a novel BaSO4 contrast agent has a favorable tagging efficacy, patient acceptability, and accuracy.

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Acknowledgements

The scientific guarantor of this publication is K. Mitsuzaki, MD, PhD. This study was funded by Fushimi Pharmaceutical Co., Ltd. for the approval of a pharmaceutical product, and conducted in compliance with GCP (ICH-G6). Akira Yoshino of Fushimi Pharmaceutical Co., Ltd. conducted the statistical analysis.

Funding

This study was funded by Fushimi Pharmaceutical Co., Ltd. for the approval of a pharmaceutical product, and conducted in compliance with GCP (ICH-G6).

Author information

Authors and Affiliations

  1. Center for Preventive Medicine, Saiseikai Kumamoto Hospital, 5-3-1 Chikami, Minami-ku, Kumamoto, Kumamoto, Japan

    Katsuhiko Mitsuzaki

  2. Department of Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan

    Gen Iinuma & Mototaka Miyake

  3. Department of Radiology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan

    Tsuyoshi Morimoto

  4. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagito, Gifu, Gifu, Japan

    Hideto Tomimatsu

Authors
  1. Katsuhiko Mitsuzaki
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  2. Gen Iinuma
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  3. Tsuyoshi Morimoto
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  4. Mototaka Miyake
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  5. Hideto Tomimatsu
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Corresponding author

Correspondence to Katsuhiko Mitsuzaki.

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Conflict of interest

All authors of this manuscript declare no relationship with any companies.

Research ethics and patient consent

Saiseikai Kumamoto Hospital Institutional Review Board approved this study (CTC-2310/P301). Written informed consent was obtained from all patients in this study.

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Mitsuzaki, K., Iinuma, G., Morimoto, T. et al. Computed tomographic colonography with a reduced dose of laxative using a novel barium sulfate contrast agent in Japan. Jpn J Radiol 37, 245–254 (2019). https://doi.org/10.1007/s11604-018-0800-x

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  • DOI: https://doi.org/10.1007/s11604-018-0800-x

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