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Value of Preoperative Hematological Parameters in the Prognosis of Gastric Cancer Patients Undergoing a Total Gastrectomy

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Abstract

Objective

This study aimed to evaluate the relationships between the albumin/globulin ratio (AGR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) and clinicopathological information for gastric cancer patients. In addition, the prognostic values of these hematological parameters for resectable gastric cancer patients undergoing a total gastrectomy were determined.

Methods

A total of 245 patients with gastric cancer who underwent a total gastrectomy at our hospital between January 1, 2005, and December 30, 2015, were enrolled into this study. The preoperative AGR, NLR, and PLR in the serum samples of the patients were measured. The relationships between the hematological parameters and the disease-free survival (DFS) as well as overall survival (OS) were analyzed by statistical analysis.

Results

The cutoff values of AGR, NLR, and PLR were 1.57, 3.5, and 193, respectively. Univariate analyses demonstrated that a low AGR, a high NLR, and a high PLR were significant risk factors for a poor prognosis. According to multivariate analysis, a high PLR was found to be independently associated with a poor survival. Additionally, when age was considered as a stratified factor, univariate analyses demonstrated that a low AGR had the tendency to be correlated with a shorter DFS in nonelderly patients (<65 years old). A low AGR was significantly correlated with a shorter DFS and OS in elderly patients (≥65 years old).

Conclusion

AGR, NLR, and PLR are independent risk factors associated with a poor gastric cancer survival by univariate analysis, and AGR is an independent risk factor for predicting DFS and OS in elderly patients (≥65 years old) with gastric cancer after total gastrectomy.

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Acknowledgments

The authors thank Dr. Pan Jianhong for his help with the statistical analysis.

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Authors and Affiliations

  1. Oncology Department, Peking University First Hospital, Beijing, 100034, China

    Xi-shan Zhu, Fei-yan Ma & Shi-kai Wu

  2. Pathology Department, Peking University First Hospital, Beijing, 100034, China

    Ye Zhao

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  1. Xi-shan Zhu
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  2. Ye Zhao
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  4. Shi-kai Wu
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Corresponding author

Correspondence to Shi-kai Wu.

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The authors declare that they have no conflicts of interest.

Additional information

This study was supported by the Science Foundation of Peking University First Hospital.

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Zhu, Xs., Zhao, Y., Ma, Fy. et al. Value of Preoperative Hematological Parameters in the Prognosis of Gastric Cancer Patients Undergoing a Total Gastrectomy. CURR MED SCI 42, 348–356 (2022). https://doi.org/10.1007/s11596-022-2514-7

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  • DOI: https://doi.org/10.1007/s11596-022-2514-7

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