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Influencing Factors for Erectile Dysfunction of Young Adults with No Response to PDE5i

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Summary

Erectile dysfunction (ED) is a common male disorder. Although orally-administered phosphodiesterase type 5 inhibitors (PDE5 inhibitors) are now recognized as the primary pharmacological treatment method for ED, 20%–30% of the patients treated with PDE5 inhibitors exhibit no significant effects. This study aims to investigate the influencing factors of ED in young adults with no response to PDE5 inhibitors. ED patients who would take PDE5 inhibitors were included and investigated with a questionnaire. Patients with no response to PDE5 inhibitors (tadalafil and sildenafil) served as study group, and those with response to PDE5 inhibitors as control group. Then Chi square test and logistic regression analysis were applied to find the potential influencing factors. In total, 378 ED patients were included. Ninety-three (24.6%) cases were non-responsive to PDE5 inhibitors, and the remaining 285 (75.4%) responded to PDE5 inhibitors. In multiple logistic regression analysis, we found that history of drinking (OR=3.152; 95%CI 1.672–6.975), spousal noncooperation (OR=2.994; 95%CI 1.589–5.638), number of fixed sex partners (OR=0.358; 95%CI 0.132–0.651), duration of ED (OR=3.356; 95%CI 1.352–8.333), and depression (OR=3.689; 95%CI 1.579–8.979) could be the influencing factors for ED patients’ non-response to PDE5 inhibitors. In conclusion, history of drinking, spousal noncooperation, number of fixed sex partner, long duration of ED, and depression could be the influencing factors for ED patients’ non-response to PDE5 inhibitors. Patients and doctors should pay attention to these factors.

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  1. Both authors contributed equally to this study.

Authors and Affiliations

  1. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Jin Wang, Yan-li Wang, Yao He, Sen Li, You-peng Zhang, Yong-biao Cheng, Jia-lun Guo, Lin Sun, Yu Xin, Yong Tang, Zhao-hui Zhu & Han-qing Zeng

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  1. Jin Wang
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  2. Yan-li Wang
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  3. Yao He
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  4. Sen Li
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  5. You-peng Zhang
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  8. Lin Sun
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  9. Yu Xin
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  11. Zhao-hui Zhu
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Correspondence to Han-qing Zeng.

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The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work.

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Wang, J., Wang, Yl., He, Y. et al. Influencing Factors for Erectile Dysfunction of Young Adults with No Response to PDE5i. CURR MED SCI 41, 529–534 (2021). https://doi.org/10.1007/s11596-021-2380-8

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  • DOI: https://doi.org/10.1007/s11596-021-2380-8

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