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Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion

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Summary

p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA). In order to investigate the association between p53 polymorphism at codon 72 and RSA, we conducted this meta-analysis. Pubmed, Embase and Web of science were used to identify the eligible studies. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of the association. Six studies containing 937 cases of RSA and 830 controls were included, and there was one study deviated from Hardy-Weinberg equilibrium (HWE). There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14–2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02–2.12) whether the study that was deviated from HWE was eliminated or not. A significant association was observed in allelic model (Pro vs. Arg; OR=1.28, 95% CI: 1.04–1.57) after exclusion of the study that was deviated from HWE. No association was noted in recessive model (Pro/Pro+Pro/Arg vs. Arg/Arg; OR=1.05, 95% CI: 0.86–1.30) and co-dominant model (Pro/Arg vs. Arg/Arg; OR=0.96, 95% CI: 0.77–1.19). Subgroup analysis by ethnicity also indicated a significant association between p53 polymorphism at codon 72 and RSA in Caucasian group. No heterogeneity and publication bias were found. Our meta-analysis implied that p53 polymorphism at codon 72 carries high maternal risk of RSA.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ying Zhang  (张 莹), Yuan-yuan Wu  (吴媛媛), Fu-yuan Qiao  (乔福元) & Wan-jiang Zeng  (曾万江)

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  1. Ying Zhang  (张 莹)
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  2. Yuan-yuan Wu  (吴媛媛)
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  3. Fu-yuan Qiao  (乔福元)
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  4. Wan-jiang Zeng  (曾万江)
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Corresponding author

Correspondence to Wan-jiang Zeng  (曾万江).

Additional information

This project was supported by The National Science and Technology Pillar of China program during the Twelfth Five-Year Plan Period (No. 2014BAI 05B05).

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Zhang, Y., Wu, Yy., Qiao, Fy. et al. Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 36, 402–405 (2016). https://doi.org/10.1007/s11596-016-1599-2

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  • DOI: https://doi.org/10.1007/s11596-016-1599-2

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