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Comparative study of DSC-PWI and 3D-ASL in ischemic stroke patients

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Abstract

The purpose of this study was to quantitatively analyze the relationship between three dimensional arterial spin labeling (3D-ASL) and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) in ischemic stroke patients. Thirty patients with ischemic stroke were included in this study. All subjects underwent routine magnetic resonance imaging scanning, diffusion weighted imaging (DWI), magnetic resonance angiography (MRA), 3D-ASL and DSC-PWI on a 3.0T MR scanner. Regions of interest (ROIs) were drawn on the cerebral blood flow (CBF) maps (derived from ASL) and multi-parametric DSC perfusion maps, and then, the absolute and relative values of ASL-CBF, DSC-derived CBF, and DSC-derived mean transit time (MTT) were calculated. The relationships between ASL and DSC parameters were analyzed using Pearson’s correlation analysis. Receiver operative characteristic (ROC) curves were performed to define the thresholds of relative value of ASL-CBF (rASL) that could best predict DSC-CBF reduction and MTT prolongation. Relative ASL better correlated with CBF and MTT in the anterior circulation with the Pearson correlation coefficients (R) values being 0.611 (P<0.001) and–0.610 (P<0.001) respectively. ROC curves demonstrated that when rASL ≤0.585, the sensitivity, specificity and accuracy for predicting ROIs with rCBF<0.9 were 92.3%, 63.6% and 76.6% respectively. When rASL ≤0.952, the sensitivity, specificity and accuracy for predicting ROIs rMTT>1.0 were 75.7%, 89.2% and 87.8% respectively. ASL-CBF map has better linear correlations with DSC-derived parameters (DSC-CBF and MTT) in anterior circulation in ischemic stroke patients. Additionally, when rASL is lower than 0.585, it could predict DSC-CBF decrease with moderate accuracy. If rASL values range from 0.585 to 0.952, we just speculate the prolonged MTT.

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Authors and Affiliations

  1. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Shui-xia Zhang  (张水霞), Yi-hao Yao  (姚义好), Shun Zhang  (张 顺), Wen-jie Zhu  (朱文杰), Xiang-yu Tang  (汤翔宇), Yuan-yuan Qin  (覃媛媛), Ling-yun Zhao  (赵凌云), Cheng-xia Liu  (刘城霞) & Wen-zhen Zhu  (朱文珍)

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  1. Shui-xia Zhang  (张水霞)
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  2. Yi-hao Yao  (姚义好)
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  3. Shun Zhang  (张 顺)
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  4. Wen-jie Zhu  (朱文杰)
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  5. Xiang-yu Tang  (汤翔宇)
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  6. Yuan-yuan Qin  (覃媛媛)
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  7. Ling-yun Zhao  (赵凌云)
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  8. Cheng-xia Liu  (刘城霞)
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  9. Wen-zhen Zhu  (朱文珍)
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Corresponding author

Correspondence to Wen-zhen Zhu  (朱文珍).

Additional information

This project was supported by grants from the 12th Five-year Science and Technology Support Program of China (No. 2011BAI08B10) and the National Natural Science Foundation of China (No. 81171308, No. 81570462)

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Zhang, Sx., Yao, Yh., Zhang, S. et al. Comparative study of DSC-PWI and 3D-ASL in ischemic stroke patients. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 35, 923–927 (2015). https://doi.org/10.1007/s11596-015-1529-8

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  • DOI: https://doi.org/10.1007/s11596-015-1529-8

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