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Efficacy and safety of tacrolimus vs. cyclophosphamide for idiopathic membranous nephropathy: A meta-analysis of Chinese adults

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Summary

The efficacy and safety of tacrolimus (TAC) and cyclophosphamide (CTX) in the treatment of idiopathic membranous nephropathy (IMN) were compared in Chinese adult patients using a meta- analysis of the available literatures. Randomized controlled clinical trials (RCTs) of the treatment of primary IMN with TAC or CTX combined with corticosteroids in the English databases PubMed, Embase and Cochrane, as well as Chinese databases, were searched. Qualified studies were subjected to quality assessment and meta-analysis. A total of 8 RCTs, including 359 Chinese patients, were included in the meta-analysis. The complete remission rate and overall remission rate in the TAC treatment group after 6 months of treatment were higher than those in the CTX treatment group. No significant difference in remission rate was found after 12 months of treatment. There was no significant difference in the adverse reaction between the two groups at the 6th or 12th months. TAC-based treatment was associated with a faster response than CTX at the 6th month, but there was no significant difference between the two groups at 12th month in Chinese adults. Further study is needed to evaluate the long-term efficacy and safety of this treatment regimen.

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Authors and Affiliations

  1. Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Zhen-qiong Li  (李贞琼), Man-li Hu  (胡曼丽), Chun Zhang  (张 春) & Yu-mei Wang  (王玉梅)

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  1. Zhen-qiong Li  (李贞琼)
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  2. Man-li Hu  (胡曼丽)
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  3. Chun Zhang  (张 春)
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  4. Yu-mei Wang  (王玉梅)
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Corresponding author

Correspondence to Yu-mei Wang  (王玉梅).

Additional information

This project was supported by the National Natural Science Foundation of China (No. 30800523 and 81570657), and a grant from Hubei Province Health and Family Planning Commission (No. WJ2015MB013).

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Li, Zq., Hu, Ml., Zhang, C. et al. Efficacy and safety of tacrolimus vs. cyclophosphamide for idiopathic membranous nephropathy: A meta-analysis of Chinese adults. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 35, 623–628 (2015). https://doi.org/10.1007/s11596-015-1480-8

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  • DOI: https://doi.org/10.1007/s11596-015-1480-8

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