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Central venous catheter-related thrombosis in senile male patients: New risk factors and predictors

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Summary

Central venous catheterization (CVC)-related venous thrombosis is a common but serious clinical complication, thus prevention and treatment on this problem should be extensively investigated. In this research, we aimed to investigate the incidence rate of CVC-related venous thrombosis in senile patients and give a further discussion on the related risk factors and predictors. A total of 324 hospitalized senile male patients subjected to CVC were selected. Retrospective investigation and analysis were conducted on age, underlying diseases, clinical medications, catheterization position and side, catheter retention time, and incidence of CVC-related venous thrombosis complications. Basic laboratory test results during catheterization and thrombogenesis were also collected and analyzed. Among the 324 patients, 20 cases (6.17%) of CVC-related venous thrombosis were diagnoseds. The incidence rate of CVC-related venous thrombosis in subclavian vein catheterization was significantly lower than that in femoral vein catheterization (P<0.01) and that in internal jugular vein catheterization (P<0.05). No statistically significant difference was found between femoral vein catheterization and internal jugular vein catheterization (P<0.05). Previous venous thrombosis history (P<0.01), high lactate dehydrogenase level (P<0.01), low high-density lipoprotein (HDL) level (P<0.05), and low albumin level (P<0.05) were found as risk factors or predictors of CVC-related venous thrombosis in senile male patients. Subclavian vein catheterization was the most appropriate choice among senile patients to decrease the incidence of CVC-related venous thrombosis. Previous venous thrombosis history, high lactate dehydrogenase level, low HDL level, and low albumin level were important risk factors in predicting CVC-related venous thrombosis.

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References

  1. Kujur R, Rao SM, Badwaik G, et al. Thrombosis associated with right internal jugular central venous catheters: A prospective observational study. Indian J Crit Care Med, 2012,16(1):17–21

    Article  PubMed Central  PubMed  Google Scholar 

  2. McGee DC, Gould MK. Preventing complications of central venous catheterization. N Engl J Med, 2003,348(12):1123–1133

    Article  PubMed  Google Scholar 

  3. Massicotte MP, Dix D, Monagle P, et al. Central venous catheter related thrombosis in children: analysis of the Canadian Registry of Venous Thromboembolic Complications. J Pediatr, 1998,133(6):770–776

    Article  CAS  PubMed  Google Scholar 

  4. Monagle P, Adams M, Mahoney M, et al. Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry. Pediatr Res, 2000,47(6):763–766

    Article  CAS  PubMed  Google Scholar 

  5. Debourdeau P, Chahmi DK, Zammit C, et al. Venous thromboembolism associated with long-term use of central venous catheter in cancer patients. Pathol Biol, 2008,56(4):211–219

    Article  CAS  PubMed  Google Scholar 

  6. Verso M, Agnelli G. Venous thromboembolism associated with long-term use of central venous catheters in cancer patients. J Clin Oncol, 2003,21(19):3665–3675

    Article  PubMed  Google Scholar 

  7. Monika J, Anna C, Dariusz P, et al. Incidence and risk factors for central venous catheter-related thrombosis in hematological patients. Medical Oncology, 2014,31(1):1–7

    Google Scholar 

  8. Park CK, Paes BA, Nagel K, et al. Neonatal central venous catheter thrombosis: diagnosis, management and outcome. Blood Coagul Fibrinolysis, 2014,25(2):97–106

    Article  PubMed  Google Scholar 

  9. Curigliano G, Balduzzi A, Cardillo A, et al. Low-dose aspirin for the prevention of venous thromboembolism in breast cancer patients treated with infusional chemotherapy after insertion of central vein catheter. Support Care Cancer, 2007,15(10):1213–1217

    Article  PubMed  Google Scholar 

  10. Hovens MMC, Snoep JD, Tamsma JT, et al. Aspirin in the prevention and treatment of venous thromboembolism. J Thromb Haemost, 2006,4(7):1470–1475

    Article  CAS  PubMed  Google Scholar 

  11. Boersma RS, Jie KS, Verbon A, et al. Thrombotic and infectious complications of central venous catheters in patients with hematological malignancies. Ann Oncol, 2008,19(3):433–442

    Article  CAS  PubMed  Google Scholar 

  12. Monika J, Anna C, Dariusz P, et al. Incidence and risk factors for central venous catheter-related thrombosis in hematological patients. Med Oncol, 2014,31(1):1–7

    Google Scholar 

  13. Boersma RS, Jie KS, Verbon A, et al. Thrombotic and infectious complications of central venous catheters in patients with hematological malignancies. Ann Oncol 2008,19(3):433–442

    Article  CAS  PubMed  Google Scholar 

  14. Rooden CJ, Tesselaar ME, Osanto S, et al. Deep vein thrombosis associated with central venous catheters—a review. J Thromb Haemost, 2005,3(11):2409–2419

    Article  CAS  PubMed  Google Scholar 

  15. Rosovsky RP, Kuter DJ. Catheter-related thrombosis in cancer patients: pathophysiology, diagnosis, and management. Hematol Oncol Clin North Am, 2005,19(1):183–202

    Article  PubMed  Google Scholar 

  16. Richters A, van Vliet M, Peer PG, et al. Incidence of and risk factors for persistent gram-positive bacteraemia and catheter-related thrombosis in haematopoietic stem cell transplantation. Bone Marrow Transplant, 2014,49(2):264–269

    Article  CAS  PubMed  Google Scholar 

  17. Merrer J, De Jonghe B, Golliot F, et al. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA, 2001,286(6):700–707

    Article  CAS  PubMed  Google Scholar 

  18. Timsit JF, Farkas JC, Boyer JM, et al. Central vein catheter-related thrombosis in intensive care patients: incidence, risk factors, and relationship with catheter-related sepsis. Chest, 1998,114(1):207–213

    Article  CAS  PubMed  Google Scholar 

  19. Gentile A, Petit L, Masson F, et al. Subclavian central venous catheter-related thrombosis in trauma patients: incidence, risk factors and influence of polyurethane type. Crit Care, 2013,17(3):103

    Article  Google Scholar 

  20. MacRae JM, Ahmed A, Johnson N, et al. Central vein stenosis: a common problem in patients on hemodialysis. ASAIO J, 2005,51(1):77–81

    Article  PubMed  Google Scholar 

  21. Naroienejad M, Saedi D, Rezvani A. Prevalence of central vein stenosis following catheterization in patients with end-stage renal disease. Saudi J Kidney Dis Transplant, 2010,21(5):975–978

    Google Scholar 

  22. Cortelezzi A, Fracchiolla NS, Maisonneuve P. Central venous catheter-related complications in patients with hematological malignancies: a retrospective analysis of risk factors and prophylactic measures. Leuk Lymphuma, 2003,44(9):1495–1501

    Article  Google Scholar 

  23. Blom JW, Doggen CJ, Osanto S, et al. Malignancies prothrombotic mutations and the risk of venous thrombosis. JAMA, 2005,293(6):715–722

    Article  CAS  PubMed  Google Scholar 

  24. Fonseca V, Desouza C, Asnani S, et al. Nontraditional risk factors for cardiovascular disease in diabetes. Endocr Rev, 2004,25(1):153–175

    Article  CAS  PubMed  Google Scholar 

  25. Joks M, Czyz A, Poplawski D, et al. Incidence and risk factors for central venous catheter-related thrombosis in hematological patients. Med Oncol, 2014,31(1):772

    Article  PubMed Central  PubMed  Google Scholar 

  26. Lechner D, Weltermann A. Pathophysiology of chemotherapy- associated thrombosis. Hamostaseologie, 2009,29(1):112–120

    CAS  PubMed  Google Scholar 

  27. Baskin J L, Pui C-H, R-eiss U, et al. Management of occlusion and thrombosis associated with long-term indwelling central venous catheters. Lancet, 2009,374(9684):159–169

    Article  PubMed Central  PubMed  Google Scholar 

  28. Cheng Y, Cui T, Fu P, et al. Dyslipidemia is associated with tunneled-cuffed catheter-related central venous thrombosis in hemodialysis patients: a retrospective, multicenter study. Artif Organs, 2013,37(8):155–161

    Article  Google Scholar 

  29. Anthony-Lizarraga W, Dalia S, Reinert SE, et al. Venous thrombosis in patients with chronic liver disease. Blood Coagul Fibrinolysis, 2010,21(5):431–435

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Gao Liu  (柳高).

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Liu, G., Fu, Zq., Zhu, P. et al. Central venous catheter-related thrombosis in senile male patients: New risk factors and predictors. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 35, 445–449 (2015). https://doi.org/10.1007/s11596-015-1451-0

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  • DOI: https://doi.org/10.1007/s11596-015-1451-0

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