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Effect of VEGF/GREDVY Modified Surface on Vascular Cells Behavior

  • Biomaterial
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Journal of Wuhan University of Technology-Mater. Sci. Ed. Aims and scope Submit manuscript

Abstract

We synthesized B-He/B-GREDVY and immobilized them on avidin-coated surfaces. To examine the immobilization of molecules in the material, the following experiments were performed: fluorescein isothiocyanate (FITC) fluorescence staining, water contact angle and atomic force microscopy (AFM) measurements. Besides, the biological evaluation experiments were also performed, such as platelets adhesion and activation, the culturing of smooth muscle cells (SMC) and endothelial cells (EC). These experimental results show that the modified surfaces could prevent the hyperproliferation of SMC, and promote the proliferation and migration of EC and EPC. Furthermore, the adding of VEGF improved the EC adhesion in a dynamic environment. Generally, it is expected that the modified surfaces could be used to accelerate the formation of the newly endothelial layer for the construction of platforms for coronary artery stent therapy.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China

    Lai Wei  (魏来), Jianying Tan, Li Li, Huanran Wang, Sainan Liu, Zheng Zeng, Tao Liu, Jian Wang, Junying Chen  (陈俊英) & Yajun Weng

Authors
  1. Lai Wei  (魏来)
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  2. Jianying Tan
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  3. Li Li
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  4. Huanran Wang
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  5. Sainan Liu
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  6. Zheng Zeng
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  7. Tao Liu
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  8. Jian Wang
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  9. Junying Chen  (陈俊英)
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  10. Yajun Weng
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Corresponding author

Correspondence to Junying Chen  (陈俊英).

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All authors declare that there are no competing interests.

Additional information

Funded by the National Natural Science Foundation of China (Nos.32271377 and 31870955) and the National Key Research and Development of China (No.2020YFC1107300-03)

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Wei, L., Tan, J., Li, L. et al. Effect of VEGF/GREDVY Modified Surface on Vascular Cells Behavior. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 39, 244–254 (2024). https://doi.org/10.1007/s11595-024-2877-7

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  • DOI: https://doi.org/10.1007/s11595-024-2877-7

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