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Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

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Abstract

We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy (1H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.

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Authors and Affiliations

  1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Materials Science and Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, China

    Shouxia Wang  (王守霞), Zhiyi Hu  (胡执一), Jie Hu, Junli Li  (李俊丽), Wei Geng, Baolian Su & Xiaoyu Yang  (阳晓宇)

  2. School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai, 519082, China

    Wei Geng & Xiaoyu Yang  (阳晓宇)

  3. Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, 519000, China

    Wei Geng & Xiaoyu Yang  (阳晓宇)

  4. Laboratory of Inorganic Materials Chemistry (CMI), University of Namur, 61, rue de Bruxelles, B-5000, Namur, Belgium

    Baolian Su

  5. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA

    Xiaoyu Yang  (阳晓宇)

  6. School of Materials Science and Technology, South China University of Technology, Guangzhou, 510640, China

    Zhiming Qiu

Authors
  1. Shouxia Wang  (王守霞)
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  2. Zhiyi Hu  (胡执一)
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  3. Jie Hu
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  4. Zhiming Qiu
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  5. Junli Li  (李俊丽)
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  6. Wei Geng
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  7. Baolian Su
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  8. Xiaoyu Yang  (阳晓宇)
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Corresponding authors

Correspondence to Junli Li  (李俊丽) or Xiaoyu Yang  (阳晓宇).

Additional information

Funded by National Natural Science Foundation of China (Nos. 51861135313, U1663225, U1662134, 21711530705, 21673282, 21473246), Fundamental Research Funds for the Central Universities (Nos.19lgpy112, 19lgzd16, 2019IB005), National Key R&D Program of China (No.2017YFC1103800), Program for Changjiang Scholars and Innovative Research Team in University (No. IRT_15R52), International Science & Technology Cooperation Program of China (No.2015DFE52870), and Jilin Province Science and Technology Development Plan (No.20180101208JC)

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Wang, S., Hu, Z., Hu, J. et al. Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 35, 658–664 (2020). https://doi.org/10.1007/s11595-020-2303-8

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  • DOI: https://doi.org/10.1007/s11595-020-2303-8

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