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Hydroxyapatite/β-tricalcium phosphate composite for guiding bone tissue growth into a titanium tube in 8 mm dog tibia cavity defects

  • Organic Materials
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Journal of Wuhan University of Technology-Mater. Sci. Ed. Aims and scope Submit manuscript

Abstract

We developed a fixation method and evaluate bone regrowth in the cavities of a ϕ4 mm× 8 mm titanium (Ti) tube through porous hydroxyapatite (HAP)/β-tricalcium phosphate (β-TCP) composite filling (group A), chitosan/calcium phosphate composite filling (group B), and HAP particle modification (group C). After 2 and 5 months of implantation in dog tibia defects, new bone formation in the three groups was studied by histology and histomorphometry. Group A displayed the most bone regenerated area in both 2 and 5 months post-operation. The chitosan/calcium phosphate composite in group B mostly degraded 2 months after implantation, leading to fibrous tissue invasion after 5 months. By contrast, less bone formation was observed in group C. These results indicated that filling the cavities of metal prostheses with a porous HAP/β-TCP composite can be used for stable long-term fixation in clinical settings.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436, China

    Jixiang Zhu  (朱继翔) & Xiaoming Chen  (陈晓明)

  2. Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan, 430070, China

    Jing Wang

  3. Animal Experiment Center, Zhongnan Hospital of Wuhan University, Wuhan, 430077, China

    Weimin Chen

Authors
  1. Jixiang Zhu  (朱继翔)
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  2. Xiaoming Chen  (陈晓明)
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  3. Jing Wang
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  4. Weimin Chen
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Corresponding author

Correspondence to Xiaoming Chen  (陈晓明).

Additional information

Funded by the Science and Technology Planning Project of Guangdong Province (2013B010402019), the Natural Science Foundation of Guangdong Province (2015A030310345), and the Medical Scientific Research Foundation of Guangdong Province (A2015352)

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Zhu, J., Chen, X., Wang, J. et al. Hydroxyapatite/β-tricalcium phosphate composite for guiding bone tissue growth into a titanium tube in 8 mm dog tibia cavity defects. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 31, 468–473 (2016). https://doi.org/10.1007/s11595-016-1393-9

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  • DOI: https://doi.org/10.1007/s11595-016-1393-9

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