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Preparation and characterization of alginate-hyaluronic acid-chitosan based composite gel beads

  • Biomaterials
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Abstract

The aim of this study was to fabricate composite gel beads based on natural polysaccharides. Hyaluronic acid (HA) and Chitosan (CS) were successfully admixed with Ca2+/alginate (SA) gel system to produce SA/HA/CS gel beads by dual crosslinking: the ionic gelation and the polyelectrolyte complexation. The preparation procedure was that the weight ratio of SA (2%, m/v) to HA (2%, m/v) was kept at 2:1, then the mixture was dripped into the Ca2+ solution for ion-crosslinking, and finally polyelectrolyte crosslinked with 2% low molecular weight CS (LMW-CS) for 1.5 hours. The optimal formulation was achieved by adjusting the concentration and the weight ratio of SA, HA and LMW-CS. Due to the incorporation of HA and LMWCS, the swelling ratio of the beads at pH 7.4 was increased up to 120, and the time for the maximum swelling degree was prolonged to 7.5 h. The swelling behavior was obviously improved compared to the pure SA/Ca2+ system. The preliminary results clearly suggest that the SA/HA/CS gel beads may be a potential candidate for biomedical delivery vehicles.

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Authors and Affiliations

  1. College of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, China

    Yan Hu  (胡燕), Xiaoying Dong, Dan Zhao, Han Cheng  (程寒) & Xincai Xiao

  2. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Mengzhu Zheng

Authors
  1. Yan Hu  (胡燕)
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  2. Mengzhu Zheng
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  3. Xiaoying Dong
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  4. Dan Zhao
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  5. Han Cheng  (程寒)
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  6. Xincai Xiao
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Corresponding author

Correspondence to Han Cheng  (程寒).

Additional information

Funded by the National Natural Science Foundation of China (No. 81401510)

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Hu, Y., Zheng, M., Dong, X. et al. Preparation and characterization of alginate-hyaluronic acid-chitosan based composite gel beads. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 30, 1297–1303 (2015). https://doi.org/10.1007/s11595-015-1311-6

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  • DOI: https://doi.org/10.1007/s11595-015-1311-6

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