Abstract
Poly(vinyl alcohol)/collagen (PVA/COL) micro-nanofibers were successfully prepared by electrospinning process. Water, green, and non-toxic was used as the solvent. The electrospun mats consisted of micro-nanoscale fibers with mean diameter ranging from approximately 363 nm to 179 nm. It was observed that the mean diameters of PVA/COL electrospun fibers decreased with increasing collagen content. The effects of PVA/COL blending ratio on the rheological behavior of PVA/COL blended solutions were investigated by rotate rheometer. It was found that PVA/COL blended solutions behaved as Non-Newtonian fluids. With increasing collagen content, the Non-Newtonian index (n) of PVA/COL blended solutions decreased. Meanwhile, a linear relationship was found between the Non-Newtonian index (n) and the mean diameters of the PVA/COL micronanofibers. The chemical structures of PVA/COL electrospun fibers were also characterized by FTIR.
Similar content being viewed by others
References
Nandana B, Subhas CK. Electrospinning: A Fascinating Fiber Fabrication Technique[J]. Biotechnol. Adv., 2010, 28(3): 325–347
Sell SA, McClure MJ, Garg K, et al. Electrospinning of Collagen/ biopolymers for Regenerative Medicine and Cardiovascular Tissue Engineering[J]. Adv. Drug Deliv. Rev., 2009,61(12): 1007–1019
Zhong SP, Teo WE, Zhu X, et al. Development of a Novel Collagen- GAG Nanofibrous Scaffold via Electrospinning[J]. Mater. Sci. Eng. C, 2007, 27(2): 262–266
Scotchford CA, Cascone MG, Downes S, et al. Osteoblast Responses to Collagen-PVA BioartiÞcial Polymers in Vitro: the Effects of Crosslinking Method and Collagen Content[J]. Biomaterials, 1998, 19: 1–11
Ottania V, Raspantib M, Ruggeria A. Collagen Structure and Functional Implications[J]. Micron, 2001, 32: 251–260
Friess W. Collagen-Biomaterial for Drug Delivery[J]. Eur. J. Pharm. Biopharm., 1998, 45(2): 113–136
Matthews JA, Wnek GE, Simpson DG, et al. Electrospinning of Collagen Nanofibers[J]. Biomacromolecules, 2002, 3(2): 232–238
Dong B, Arnoult O, Smith ME, et al. Wnek. Electrospinning of Collagen Nanofiber Scaffolds from Benign Solvents[J]. Macromol. Rapid. Commun., 2009, 30(7): 539–542
Li WJ, Mauck RL, Tuan RS. Electrospun Nanofibrous Scaffolds: Production, Characterization, and Applications for Tissue Engineering and Drug Delivery[J]. J. Biomed. Nanotechnol., 2005, 1(3): 259–275
Chen Z, Mo X, Qing F. Electrospinning of Collagen-Chitosan Complex[J]. Mater. Lett., 2007, 61(16): 3490–3494
Huang C, Chen R, Ke Q, et al. Electrospun Collagen-Chitosan- TPU Nanofibrous Scaffolds for Tissue Engineered Tubular Grafts[J]. Colloids. Surf. B Biointerfaces, 2011, 82(2): 307–315
Zhong S, Teo WE, Zhu X. An Aligned Nanofibrous Collagen Scaffold by Electrospinning and its Effects on in Vitro Fibroblast Culture[J]. J. Biomed. Mater. Res. A, 2006, 79A: 456–463
Chen Z, Wei B, Mo XM. Diameter Control of Electrospun Chitosan- Collagen Fibers[J]. J. Polym. Sci., Part B: Polym. Phys., 2009, 47(19): 1949–1955
Boland ED, Matthews JA, Pawlowski KJ, et al. Electrospinning Collagen and Elastin: Preliminary Vascular Tissue Engineering[J]. Front. Biosci., 2004, 9: 1422–1432
Teng SH, Lee EJ, Wang P, et al. Collagen/Hydroxyapatite Composite Nanofibers by Electrospinning[J]. Mater. Lett., 2008, 62(17-18): 3055–3058
Zeugolis DI, Khew ST, Yew ESY, et al. Electrospinning of Pure Collagen Nano-fibres-Just an Expensive Way to Make Gelatin?[J]. Biomaterials, 2008, 29(15): 2293–2305
Burck J, Heissler S, Geckle U, et al. Resemblance of Electrospun Collagen Nanofibers to Their Native Structure[J]. Langmuir, 2013, 29(5): 1562–1572
Chen JP, Chang GY, Chen JK. Electrospun Collagen/Chitosan Nanofibrous Membrane as Wound Dressing[J]. Colloids. Surf. A Physicochem. Eng Asp., 2008, 313-314: 183–188
Asran ASh, Henning S, Michler GH. Polyvinyl Alcohol-Collagen- Hydroxyapatite Biocomposite Nanofibrous Scaffold: Mimicking the Key Features of Natural Bone at the Nanoscale Level[J]. Polymer, 2010, 51(4): 868–876
Zhou J, Cao C, Ma X, et al. Electrospinning of Silk Fibroin and Collagen for Vascular Tissue Engineering[J]. Int. J. Biol. Macromol., 2010, 47(4): 514–519
Yang D, Li Y, Nie J. Preparation of Gelatin/PVA Nanofibers and Their Potential Application in Controlled release of Drugs[J]. Carbohydr. Polym., 2007, 69(3): 538–543
Zhang C, Yuan X, Wu L. Study on Morphology of Electrospun Poly(vinyl alcohol) Mats[J]. Eur. Polym. J., 2005, 41(3): 423–432
Islam MS, Karim MR. Fabrication and Characterization of Poly(vinyl alcohol)/Alginate Blend Nanofibers by Electrospinning Method[J]. Colloids. Surf. A Physicochem. Eng. Asp., 2010, 366(1-3): 135–140
Gupta P, Elkins C, Long TE, et al. Electrospinning of Linear Homopolymers of Poly(methyl methacrylate): Exploring Relationships between Fiber Formation, Viscosity, Molecular Weight and Concentration in a Good Solvent[J]. Polymer, 2005, 46(13): 4799–4810
Kong L, Ziegler GR. Rheological Aspects in Fabricating Pullulan Fibers by Electro-Wet-Spinning[J]. Food Hydrocoll., 2014, 38: 220–226
Rwei SP, Huang CC. Electrospinning PVA Solution-Rheology and Morphology Analyses[J]. Fiber. Polym., 2012, 13(1): 44–50
Zhu JX, Zhang YP, Shao HL, et al. Electrospinning and Rheology of Regenerated Bombyx Mori Silk Fibroin Aqueous Solutions: the Effects of pH and Concentration[J]. Polymer, 2008, 49(12): 2880–2885
Briscoe B, Luckham P, Zhu S. The Effects of Hydrogen Bonding upon the Viscosity of Aqueous Poly(vinyl alcohol) Solutions[J]. Polymer, 2000, 41(10): 3851–3860
Tsou SY, Lin HS, Cheng PJ, et al. Rheological Aspect on Electrospinning of Polyamide 6 Solutions[J]. Eur. Polym. J., 2013, 49(11): 3619–3629
Chae DW, Kim MH, Kim BC. Temperature Dependence of the Rheological Properties of Poly(vinylidene fluoride)/Dimethyl Acetamide Solutions and Their Electrospinning[J]. Korea-Aust. Rheol. J., 2010, 22: 229–234
Pelipenko Kristl JJ, Rošic R, et al. Interfacial Rheology: An Overview of Measuring Techniques and Its Role in Dispersions and Electrospinning[J]. Acta Pharm., 2012, 62(2): 123–140
Matthew GM, Wilkes GL, Colby RH, et al. Correlations of Solution Rheology with Electrospun Fiber Formation of Linear and Branched Polyesters[J]. Macromolecules, 2004, 37(5): 1760–1767
Author information
Authors and Affiliations
Corresponding author
Additional information
Funded by the National Natural Science Foundation of China (Nos. 21076199, 51373158) and the Department of Science and Technology of Henan Province (No. 124300510)
Rights and permissions
About this article
Cite this article
Zhang, X., Tang, K. & Zheng, X. Electrospinning and rheological behavior of poly (vinyl alcohol)/collagen blended solutions. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 30, 840–846 (2015). https://doi.org/10.1007/s11595-015-1239-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11595-015-1239-x