Abstract
Objectives Working memory performances are based on brain functional connectivity, so that connectivity may be deranged in individuals with mild cognitive impairment (MCI) and patients with dementia due to Alzheimer’s disease (ADD). Here we tested the hypothesis of abnormal functional connectivity as revealed by the imaginary part of coherency (ICoh) at electrode pairs from event-related electroencephalographic oscillations in ADD and MCI patients. Methods The study included 43 individuals with MCI, 43 with ADD, and 68 demographically matched healthy controls (HC). Delta, theta, alpha, beta, and gamma bands event-related ICoh was measured during an oddball paradigm. Inter-hemispheric, midline, and intra-hemispheric ICoh values were compared in ADD, MCI, and HC groups. Results The main results of the present study can be summarized as follows: (1) A significant increase of midline frontal and temporal theta coherence in the MCI group as compared to the HC group; (2) A significant decrease of theta, delta, and alpha intra-hemispheric coherence in the ADD group as compared to the HC and MCI groups; (3) A significant decrease of theta midline coherence in the ADD group as compared to the HC and MCI groups; (4) Normal inter-hemispheric coherence in the ADD and MCI groups. Conclusions Compared with the MCI and HC, the ADD group showed disrupted event-related intra-hemispheric and midline low-frequency band coherence as an estimate of brain functional dysconnectivity underlying disabilities in daily living. Brain functional connectivity during attention and short memory demands is relatively resilient in elderly subjects even with MCI (with preserved abilities in daily activities), and it shows reduced efficiency at multiple operating oscillatory frequencies only at an early stage of ADD.
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The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
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This article has been supported financially by a grant of the Scientific and Technological Research Council of Turkey (TÜBiTAK) (Grant number: 112S459), and Dokuz Eylul University, Department of Scientific Research Projects (Grant number: 2018.KB.SAG.084).
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Conceptualization: [Ezgi Fide] and [Görsev Yener]; Methodology: [Ezgi Fide] and [Deniz Yerlikaya]; Formal analysis and investigation: [Ezgi Fide]; Writing—original draft preparation: [Ezgi Fide]; Writing—review and editing: [Ezgi Fide], [Deniz Yerlikaya], [Görsev Yener], [Bahar Güntekin], and [Cludio Babiloni]; Supervision: [Görsev Yener], [Bahar Güntekin], and [Cludio Babiloni].
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Fide, E., Yerlikaya, D., Güntekin, B. et al. Coherence in event-related EEG oscillations in patients with Alzheimer’s disease dementia and amnestic mild cognitive impairment. Cogn Neurodyn 17, 1621–1635 (2023). https://doi.org/10.1007/s11571-022-09920-0
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DOI: https://doi.org/10.1007/s11571-022-09920-0