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Influence of fat deposition on T1 mapping of the pancreas: evaluation by dual-flip-angle MR imaging with and without fat suppression

  • Abdominal Radiology
  • Published:
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Abstract

Purpose

To evaluate the influence of fat deposition on T1 relaxation time of pancreatic parenchyma using dual-flip-angle T1 mapping with and without fat suppression.

Methods

Forty-five patients who underwent abdominal MR imaging including T1 mapping with dual-flip-angle method on 3T MRI were included. We measured T1 relaxation time of pancreatic parenchyma on the T1 map images with and without fat suppression. T1 relaxation time of bone marrow was also measured as a reference organ with abundant fat deposition. Fat signal fraction (FSF) was also measured at the same location as T1 map images. Then, the correlation between T1 relaxation time and FSF was assessed.

Results

T1 relaxation times of pancreatic parenchyma and bone marrow on the T1 map images without fat suppression showed significantly negative correlation with FSF (pancreas, r = − 0.394, P = 0.007; bone marrow, r = − 0.550, P < 0.001), while there were no significant correlations between them on the T1 map images with fat suppression. On the T1 map images without fat suppression, T1 relaxation times of pancreatic parenchyma as well as bone marrow in patients with FSF ≥ 10% were significantly shorter than those in patients with FSF < 10% (pancreas, P = 0.041; bone marrow, P = 0.005). Conversely, on the T1 map images with fat suppression, no significant differences in T1 relaxation times were found between two groups.

Conclusion

T1 relaxation time of the pancreas on T1 mapping was influenced by the presence of fat deposition. Therefore, fat suppression technique in T1 mapping will be essential for evaluating T1 relaxation time of pancreatic parenchyma.

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Authors and Affiliations

  1. Department of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan

    Mayumi Higashi, Masahiro Tanabe, Munemasa Okada, Matakazu Furukawa, Etsushi Iida & Katsuyoshi Ito

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  1. Mayumi Higashi
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  2. Masahiro Tanabe
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  3. Munemasa Okada
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  4. Matakazu Furukawa
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  5. Etsushi Iida
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  6. Katsuyoshi Ito
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Correspondence to Katsuyoshi Ito.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. Institutional review board approval for retrospective publication of data was obtained, and patients’ informed consent was waived.

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Higashi, M., Tanabe, M., Okada, M. et al. Influence of fat deposition on T1 mapping of the pancreas: evaluation by dual-flip-angle MR imaging with and without fat suppression. Radiol med 125, 1–6 (2020). https://doi.org/10.1007/s11547-019-01087-9

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  • DOI: https://doi.org/10.1007/s11547-019-01087-9

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