Abstract
Objective
This study aimed at evaluating the role of “baseline” apparent diffusion coefficent (ADC), in patients affected by head and neck cancer treated with radio-chemotherapy, as a potential marker of response to therapy.
Methods
Fifty-seven patients underwent pretreatment ADC maps. Minimum, maximum, and medium ADC were computed. Age, dose, treatment time, and ADC values were compared between the two groups (Group 1: local control; Group 2: relapse/persistence of disease) using the Student t test two-tailed unpaired. Two-tailed Fischer exact test was used to compare T stage, N stage, grading and type of treatment between two groups. We have analyzed the receiver operating characteristic (ROC) of statistically significant variables.
Results
In patients with local control, values of pre-treatment medium and minimum ADC were lower than ADC values of patients with persistent or recurrent disease, with values, respectively, of 0.83 ± 0.02 × 10–3 mm2/s and 0.59 ± 0.02 × 10–3 mm2/s (vs 0.94 ± 0.05 × 10–3 mm2/s and 0.70 ± 0.05 × 10–3 mm2/s). ROC curve analysis displayed statistical significance as regarding the medium ADC value, showing a sensitivity of 50% and a specificity of 84.8%. ROC analysis of the values minimum ADC showed a sensitivity of 42.9% and specificity of 87.9%.
Conclusion
The value of the ADC pre-treatment of patients with local control of the disease is lower than that of patients with persistent disease or recurrence.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
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Informed consent was obtained from all individual participants included in the study.
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This paper was accepted at ECR 2016 as online presentation (doi:10.1594/ecr2016/C-0109).
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Lombardi, M., Cascone, T., Guenzi, E. et al. Predictive value of pre-treatment apparent diffusion coefficient (ADC) in radio-chemiotherapy treated head and neck squamous cell carcinoma. Radiol med 122, 345–352 (2017). https://doi.org/10.1007/s11547-017-0733-y
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DOI: https://doi.org/10.1007/s11547-017-0733-y