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Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer

  • VASCULAR AND INTERVENTIONAL RADIOLOGY
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Abstract

Purpose

Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor.

Materials and methods

Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010.

Results

Time to intrahepatic progression was median 11 months (range 1.6–184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %.

Conclusions

In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in line with previous studies and underscore the need for a large prospective study using optimal chemotherapy regimens and RFA/surgery to clarify whether intense treatment protocols can prolong survival for certain patient groups.

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Conflict of interest

All authors declare no conflict of interests and no funding.

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Authors and Affiliations

  1. Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730, Herlev, Denmark

    Iben Kümler, Vibeke Kirk Parner, Malgorzata K. Tuxen, Knud Mejer Nelausen & Dorte Lisbet Nielsen

  2. Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

    Bjørn Skjoldbye

  3. Department of Surgery, Skane University Hospital, Lund, Sweden

    Magnus Bergenfeldt

Authors
  1. Iben Kümler
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  2. Vibeke Kirk Parner
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  3. Malgorzata K. Tuxen
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  4. Bjørn Skjoldbye
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  5. Magnus Bergenfeldt
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  6. Knud Mejer Nelausen
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  7. Dorte Lisbet Nielsen
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Corresponding author

Correspondence to Iben Kümler.

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Kümler, I., Parner, V.K., Tuxen, M.K. et al. Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer. Radiol med 120, 536–541 (2015). https://doi.org/10.1007/s11547-014-0489-6

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  • DOI: https://doi.org/10.1007/s11547-014-0489-6

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